Adra2a - adrenergic receptor, alpha 2a Gene

Also Known as Adra-2; Adra-2a; alpha2A; alpha2-C10; alpha2A-AR; alpha(2A)AR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11551

Summary

Enables Adrenergic Receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within G protein-coupled receptor signaling pathway and fear response. Is active in dopaminergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and sensory organ. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]

Adra2a Products (1)

mRNA Protein Name
NM_007417.5 NP_031443.4 alpha-2A adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adrenergic receptor activity IMP
IMP: Inferred from mutant phenotype
15218143 MGI
enables alpha2-adrenergic receptor activity IMP
IMP: Inferred from mutant phenotype
17992256 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9235896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15218143 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
15105370 MGI
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
1898674 MGI
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
1898674 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
11927164 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
11927164 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11927164 MGI
Cellular Component GO Annotation Evidence References Source
is active in dopaminergic synapse EXP
EXP: Inferred from Experiment
11927164 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
11927164 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
11927164 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2A adrenergic receptor

  • alpha-2A adrenoceptor

  • alpha-2A adrenoreceptor

  • alpha-2AAR

  • alpha2A-adrenergic receptor

  • subtype alpha2-C10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N8728 Aposcopolamine 98.23% Unkown
HY-163694 ADRA2A antagonist 1 Antagonist 98.02% Unkown
HY-145700 UCSF648 / Unkown
HY-RS00411 ADRA2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134125 Yohimbic acid ethyl ester Antagonist / Unkown
HY-RS17718 Adra2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24183 Adra2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra2a NCBI NCBI:150