Ncoa6 - nuclear receptor coactivator 6 Gene

Also Known as NRC; Aib3; PRIP; Trbp; RAP250

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116464

Summary

Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung Cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa6 Products (1)

mRNA	Protein	Name
NM_001276714.1	NP_001263643.1	nuclear receptor coactivator 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear glucocorticoid receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	10866662	RGD
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables nuclear vitamin D receptor binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	12189208	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10866662	RGD
enables protein domain specific binding	IMP IMP: Inferred from mutant phenotype	17536006	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	12374465	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	16738321	RGD
involved in positive regulation of peptide secretion	IMP IMP: Inferred from mutant phenotype	16738321	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10866662	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	10866662	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor coactivator 6	PPAR-interacting protein activating signal cointegrator 2 amplified in breast cancer protein 3 cancer-amplified transcriptional coactivator ASC-2 nuclear receptor-activating protein, 250 kDa peroxisome proliferator-activated receptor-interacting prot

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09094	NCOA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20060	Ncoa6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26564	Ncoa6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncoa6	NCBI	NCBI:23054