F11r - F11 receptor Gene

Also Known as Jam1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116479

Summary

Predicted to enable PDZ domain binding activity; Integrin binding activity; and protein homodimerization activity. Involved in cell differentiation; positive regulation of blood pressure; and response to radiation. Located in cytoplasmic vesicle and slit diaphragm. Biomarker of hypertension; peptic esophagitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). [provided by Alliance of Genome Resources, Apr 2022]

F11r Products (2)

mRNA Protein Name
NM_053796.1 NP_446248.1 junctional adhesion molecule A precursor
NM_053796.1 NP_446248.1 junctional adhesion molecule A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16617054 RGD
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IEP
IEP: Inferred from expression pattern
18506084 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
17420334 RGD
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
18506084 RGD
located in slit diaphragm IDA
IDA: Inferred from direct assay
19478094 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctional adhesion molecule A

  • JAM-1

  • JAM-A

  • junctional adhesion molecule 1

Recombinant F11r Proteins

Cat. No. Product Name Accession Purity
HY-P73853 JAM-A/CD321 Protein, Rat (HEK293, His) Q9JHY1 (K27-G238) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73854 JAM-A/CD321 Protein, Rat (HEK293, Fc) Q9JHY1 (K27-G238) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19600 F11r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26096 F11r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F11r NCBI NCBI:50848