Calcr - calcitonin receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116506

About Calcr

Primary_assembly 4: 31,661,273-31,736,392 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 27.7), Brain (RPKM 15.8) and 1 other tissue.

Summary

Enables Calcitonin binding activity and Calcitonin receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcr Products (2)

mRNA Protein Name
NM_053816.2 NP_446268.2 calcitonin receptor isoform 1b precursor
NM_001034015.1 NP_001029187.1 calcitonin receptor isoform 1a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcitonin binding IDA
IDA: Inferred from direct assay
7723741 RGD
enables calcitonin receptor activity IDA
IDA: Inferred from direct assay
7723741 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7723741 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in mononuclear cell differentiation IEP
IEP: Inferred from expression pattern
23110133 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15571671 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15571671 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Calcr Protein Structure

HRM

HRM: pfam02793 (85 - 153)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (161 - 471)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (163 - 188)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (197 - 219)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (273 - 300)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (312 - 332)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (347 - 376)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (390 - 417)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (423 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
Protein Preferred Names Protein Names

calcitonin receptor

  • C1A/C1B

  • CT-R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184982 Estrogen receptor-IN-2 / Unkown
HY-P11584 KBP-066A Agonist / Unkown
HY-RS01832 CALCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01833 Calcr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01834 Calcr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calcr NCBI NCBI:799