Ptpn6 - protein tyrosine phosphatase, non-receptor type 6 Gene

Also Known as Ptph6; Shp-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116689

Summary

Enables natural killer cell lectin-like receptor binding activity. Involved in response to wounding. Predicted to be located in cell-cell junction; cytoplasm; and nuclear lumen. Predicted to be part of alpha-beta T cell receptor complex. Orthologous to human PTPN6 (protein tyrosine Phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn6 Products (2)

mRNA Protein Name
NM_053908.2 NP_446360.2 tyrosine-protein phosphatase non-receptor type 6
NM_053908.2 NP_446360.2 tyrosine-protein phosphatase non-receptor type 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine receptor binding IPI
IPI: Inferred from physical interaction
11157073 RGD
enables natural killer cell lectin-like receptor binding IPI
IPI: Inferred from physical interaction
12782717 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16055727 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to macrophage colony-stimulating factor stimulus IEP
IEP: Inferred from expression pattern
11157073 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
11157073 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
11157073 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 6

  • SH2 phosphatase 1

  • protein-tyrosine phosphatase SHP-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136657 SC-43 99.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119024 BCI-137 99.84% Unkown
HY-N4150 Quercetagitrin Inhibitor 98.33% Unkown
HY-RS11429 PTPN6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17306 Ptpn6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23761 Ptpn6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpn6 NCBI NCBI:5777