Mt3 - metallothionein 3 Gene

Also Known as GIF; Mt-3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117038

Summary

Enables copper ion binding activity and zinc ion binding activity. Involved in brain development; negative regulation of hydrogen peroxide catabolic process; and negative regulation of neuron death. Located in several cellular components, including astrocyte end-foot; mitochondrial outer membrane; and synaptic vesicle. Used to study motor neuron disease. Biomarker of borna disease; cerebrovascular disease (multiple); hypothyroidism; median neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mt3 Products (1)

mRNA Protein Name
NM_053968.3 NP_446420.1 metallothionein-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
12058024 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
12058024 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of hydrogen peroxide catabolic process IDA
IDA: Inferred from direct assay
12058024 RGD
Cellular Component GO Annotation Evidence References Source
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
8911664 RGD
located in astrocyte projection IDA
IDA: Inferred from direct assay
9001723 RGD
located in axon IDA
IDA: Inferred from direct assay
8911664 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
8911664 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12058024 RGD
located in microtubule IDA
IDA: Inferred from direct assay
8911664 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
8911664 RGD
located in ribosome IDA
IDA: Inferred from direct assay
8911664 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
8911664 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metallothionein-3

  • MT-III

  • growth inhibitory factor

  • metallothionein III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128206 I3MT-3 Inhibitor 99.76% Unkown
HY-P5846 Muscarinic toxin 3 Antagonist / Unkown
HY-RS08744 MT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19565 Mt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26061 Mt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mt3 NCBI NCBI:4504