Tbp - TATA box binding protein Gene

Also Known as TFIID

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117526

Summary

Enables DNA binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of transcription, DNA-templated and spermatogenesis. Located in nucleus. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tbp Products (1)

mRNA Protein Name
NM_001004198.1 NP_001004198.1 TATA-box-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16112330 RGD
contributes to RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
7980586 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10471789 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7980586 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
8776734 RGD
Cellular Component GO Annotation Evidence References Source
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
7980586 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TATA-box-binding protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16579A Etifoxine Activator 99.27% Phase 3
HY-105056 Bretazenil Agonist 99.13% Phase 3

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16579 Etifoxine hydrochloride Activator 99.83% Yes
HY-105567A Carbiphene hydrochloride Antagonist / Unkown
HY-114811 Leptophos oxon Inhibitor / Unkown
HY-172940 TBP-134 Inducer / Unkown
HY-RS14266 TBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-105567 Carbiphene Antagonist / Unkown
HY-RS18225 Tbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24702 Tbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbp NCBI NCBI:6908