Ap2m1 - adaptor-related protein complex 2, mu 1 subunit Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11773

Summary

This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014]

Ap2m1 Products (2)

mRNA Protein Name
NM_001302970.1 NP_001289899.1 AP-2 complex subunit mu isoform 2
NM_009679.3 NP_033809.1 AP-2 complex subunit mu isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disordered domain specific binding IDA
IDA: Inferred from direct assay
18321067 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18321067 MGI
Biological Process GO Annotation Evidence References Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23676497 MGI
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
24217640 MGI
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
24217640 MGI
Cellular Component GO Annotation Evidence References Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
23676497 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24217640 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24217640 MGI
is active in synapse EXP
EXP: Inferred from Experiment
25211037 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-2 complex subunit mu

  • AP-2 mu chain

  • adapter-related protein complex 2 mu subunit

  • adaptor protein complex AP-2 subunit mu

  • adaptor protein complex AP-2, mu1

  • adaptor-related protein complex 2 subunit mu

  • adaptor-related protein complex AP-2, mu1

  • clathrin assembly protein com

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-RS00787 AP2M1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22390 Ap2m1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ap2m1 NCBI NCBI:1173