Bcl10 - B cell leukemia/lymphoma 10 Gene

Also Known as CLAP; ME10; cE10; CIPER; BCL-10; CARMEN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12042

Summary

Enables CARD domain binding activity and identical protein binding activity. Involved in Antifungal innate immune response; neural tube closure; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in MALT lymphoma; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Bcl10 Products (1)

mRNA Protein Name
NM_009740.2 NP_033870.1 B-cell lymphoma/leukemia 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CARD domain binding IPI
IPI: Inferred from physical interaction
22265677 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
16831874 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10187771 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
35263589 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell apoptotic process IDA
IDA: Inferred from direct assay
10753917 MGI
NOT acts upstream of or within B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11163238 MGI
acts upstream of or within T cell apoptotic process IDA
IDA: Inferred from direct assay
10753917 MGI
NOT acts upstream of or within T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11163238 MGI
involved in antifungal innate immune response IDA
IDA: Inferred from direct assay
22265677 MGI
acts upstream of or within cellular defense response IMP
IMP: Inferred from mutant phenotype
11163238 MGI
NOT acts upstream of or within fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
11163238 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
11163238 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
11163238 MGI
involved in non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
11163238 MGI
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
22265677 MGI
acts upstream of or within positive regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
14614861 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
10753917 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
22265677 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10753917 MGI
acts upstream of or within regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14614861 MGI
acts upstream of or within response to fungus IMP
IMP: Inferred from mutant phenotype
16862125 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
35263589 MGI
NOT acts upstream of or within thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
11163238 MGI
Cellular Component GO Annotation Evidence References Source
part of CBM complex IDA
IDA: Inferred from direct assay
22265677 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12867038 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16831874 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
14724296 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
12867038 MGI
part of polkadots IDA
IDA: Inferred from direct assay
16495340 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell lymphoma/leukemia 10

  • B-cell CLL/lymphoma 10

  • CARD-containing molecule enhancing NF-kappa-B

  • CARD-like apoptotic protein

  • CED-3/ICH-1 prodomain homologous E10-like regulator

  • cellular homolog of vCARMEN

  • cellular-E10

  • mammalian CARD-containing adapter molecule E10

Bcl10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Bcl10 Q9Z0H7 E10 Equine herpesvirus 2 Q66677
Confocal
11238466
Cross
Bcl10 Q9Z0H7 E10 Equine herpesvirus 2 Q66677
Anti Tag CoIP
11238466
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142648 MLT-985 Inhibitor 99.49% Unkown
HY-174371 INNO-220 98.60% Unkown
HY-131902 MLT-231 Inhibitor 99.55% Unkown
HY-142648A (R)-MLT-985 Inhibitor / Unkown
HY-RS01412 BCL10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17823 Bcl10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24291 Bcl10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl10 NCBI NCBI:8915