Bmpr1a - bone morphogenetic protein receptor, type 1A Gene

Also Known as ALK3; Bmpr; SKR5; ALK-3; BMPR-1A; BMPR-IA; 1110037I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12166

About Bmpr1a

Chromosome 14: 34,132,691-34,225,298 reverse strand.GRCm39:CM001007.3

This gene has 4 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 13 phenotypes. Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues.

Summary

Enables BMP binding activity; BMP Receptor activity; and enzyme activator activity. Involved in several processes, including circulatory system development; fibrous ring of heart morphogenesis; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and regionalization. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Ebstein anomaly; Wolff-Parkinson-White syndrome; chromosome 10q23 deletion syndrome; juvenile polyposis syndrome; and osteoarthritis. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr1a Products (1)

mRNA Protein Name
NM_009758.4 NP_033888.2 bone morphogenetic protein receptor type-1A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BMP binding IDA
IDA: Inferred from direct assay
11714695 MGI
enables BMP receptor activity IDA
IDA: Inferred from direct assay
11714695 MGI
enables BMP receptor activity IMP
IMP: Inferred from mutant phenotype
10564272 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15239668 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
9268344 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
16049014 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
16049014 MGI
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
10564272 MGI
acts upstream of or within Mullerian duct regression IMP
IMP: Inferred from mutant phenotype
12368913 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15136140 MGI
involved in atrioventricular node cell development IMP
IMP: Inferred from mutant phenotype
17998461 MGI
involved in atrioventricular valve development IMP
IMP: Inferred from mutant phenotype
11854453 MGI
involved in cardiac conduction system development IMP
IMP: Inferred from mutant phenotype
16037571 MGI
involved in cardiac right ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
15073157 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
15492776 MGI
acts upstream of or within central nervous system neuron differentiation IGI
IGI: Inferred from genetic interaction
15469980 MGI
involved in chondrocyte differentiation IDA
IDA: Inferred from direct assay
24098149 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
17359964 MGI
involved in dorsal aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
18667463 MGI
acts upstream of or within dorsal/ventral axis specification IMP
IMP: Inferred from mutant phenotype
12923052 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
15673568 MGI
acts upstream of or within ectoderm development IMP
IMP: Inferred from mutant phenotype
15136139 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
20043884 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
15716346 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
17359964 MGI
involved in embryonic organ development IMP
IMP: Inferred from mutant phenotype
11854453 MGI
acts upstream of or within endocardial cushion formation IMP
IMP: Inferred from mutant phenotype
16314491 MGI
involved in endocardial cushion morphogenesis IMP
IMP: Inferred from mutant phenotype
11854453 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
15136140 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16414041 MGI
involved in fibrous ring of heart morphogenesis IMP
IMP: Inferred from mutant phenotype
16037571 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16556916 MGI
acts upstream of or within heart formation IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17359964 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
16556916 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17359964 MGI
acts upstream of or within lateral mesoderm development IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16414041 MGI
acts upstream of or within mesendoderm development IMP
IMP: Inferred from mutant phenotype
15136140 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
17699604 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
16037571 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11854453 MGI
involved in negative regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
10564272 MGI
acts upstream of or within negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
17699604 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
17359964 MGI
acts upstream of or within neural crest cell development IMP
IMP: Inferred from mutant phenotype
19793887 MGI
acts upstream of or within neural plate mediolateral regionalization IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within neural plate pattern specification IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
15716346 MGI
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
7798324 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
15073157 MGI
involved in outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
15073157 MGI
acts upstream of or within paraxial mesoderm development IGI
IGI: Inferred from genetic interaction
16943278 MGI
acts upstream of or within paraxial mesoderm development IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within paraxial mesoderm structural organization IMP
IMP: Inferred from mutant phenotype
16943278 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
15716346 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: Inferred from mutant phenotype
15073157 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
17359964 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18667463 MGI
involved in positive regulation of cardiac ventricle development IMP
IMP: Inferred from mutant phenotype
18667463 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16414041 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
15716346 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
21145505 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19416967 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16037571 MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production IMP
IMP: Inferred from mutant phenotype
11854453 MGI
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18667463 MGI
NOT involved in regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15073157 MGI
involved in regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15073157 MGI
acts upstream of or within regulation of cellular senescence IGI
IGI: Inferred from genetic interaction
22729085 MGI
NOT involved in regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
20406889 MGI
NOT involved in regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
20406889 MGI
acts upstream of or within regulation of lateral mesodermal cell fate specification IGI
IGI: Inferred from genetic interaction
16943278 MGI
NOT involved in regulation of neural crest cell differentiation IMP
IMP: Inferred from mutant phenotype
15073157 MGI
NOT involved in regulation of neural crest cell fate specification IMP
IMP: Inferred from mutant phenotype
15073157 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
15716346 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
17699604 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
16943278 MGI
involved in tricuspid valve morphogenesis IMP
IMP: Inferred from mutant phenotype
16037571 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
15073157 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
11854453 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
11854453 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
29415997 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr1a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 131)

TGF_beta_GS

TGF_beta_GS: pfam08515 (204 - 231)

STKc_BMPR1a

STKc_BMPR1a: cd14220 (237 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1A

  • BMP type-1A receptor

  • BMP-2/BMP-4 receptor

  • activin receptor-like kinase 3

  • serine/threonine-protein kinase receptor R5

Recombinant Bmpr1a Proteins

Cat. No. Product Name Accession Purity
HY-P7483 BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) P36895 (Q24-R152) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4087 Cys(Npys)-(Arg)9 / Unkown
HY-RS01546 BMPR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01547 Bmpr1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01548 Bmpr1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174775 Human BMPR1A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1a NCBI NCBI:657