2. Gene
  3. Casp2 - caspase 2 Gene

Casp2 - caspase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ICH-1; Nedd2; CASP-2; NEDD-2

Gene ID: 12366 | Gene type: protein coding

About Casp2

Chromosome 6: 42,241,919-42,259,442 forward strand.GRCm39:CM000999.3

This gene has 10 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 16 phenotypes. Ubiquitous expression in thymus adult (RPKM 27.3), limb E14.5 (RPKM 22.2) and 27 other tissues.

Summary

This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced Apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]

Casp2 Products(2)

mRNA Protein Name
NM_007610.3 NP_031636.1 caspase-2 isoform 1 precursor
NM_001409539.1 NP_001396468.1 caspase-2 isoform 2

Casp2 Protein Structure

CARD_CASP2

CARD_CASP2: cd08332 (31 - 117)

CASc

CASc: smart00115 (191 - 446)

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  • 452 a.a.
Protein Preferred Names Protein Names

caspase-2

neural precursor cell expressed developmentally down-regulated protein 2

protease ICH-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0227 SHU 9119 99.95% Unkown
HY-RS01949 CASP2 Human Pre-designed siRNA Set A / Unkown
HY-RS01950 Casp2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01951 Casp2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp2 NCBI NCBI:835