Casp8 - caspase 8 Gene

Mus musculus

Also known as MACH; Mch5; FLICE; CASP-8

Gene ID: 12370 | Gene type: protein coding

About Casp8

Chromosome 1: 58,834,533-58,886,662 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 132 orthologues, 11 paralogues and is associated with 29 phenotypes. Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues.

Summary

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Casp8 Products(3)

mRNA	Protein	Name
NM_001277926.1	NP_001264855.1	caspase-8 isoform 2
NM_001080126.1	NP_001073595.1	caspase-8 isoform 1
NM_009812.2	NP_033942.1	caspase-8 isoform 1

Casp8 Protein Structure

DED_Caspase_8_r1

CASc

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

caspase-8

Fas-linked ICE-like protease

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10146	Ac-LETD-CHO	Inhibitor	/	Unkown
HY-RS01965	CASP8 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01966	Casp8 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01967	Casp8 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp8	NCBI	NCBI:841

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