Casp8 - caspase 8 Gene

Also Known as MACH; Mch5; FLICE; CASP-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12370

About Casp8

Chromosome 1: 58,834,533-58,886,662 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 132 orthologues, 11 paralogues and is associated with 29 phenotypes. Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues.

Summary

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Casp8 Products (3)

mRNA Protein Name
NM_001277926.1 NP_001264855.1 caspase-8 isoform 2
NM_001080126.1 NP_001073595.1 caspase-8 isoform 1
NM_009812.2 NP_033942.1 caspase-8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: Inferred from direct assay
9837723 MGI
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
15456877 MGI
enables cysteine-type endopeptidase activity IGI
IGI: Inferred from genetic interaction
21368763 MGI
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
31511692 MGI
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12065591 MGI
enables cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
31827281 MGI
enables endopeptidase activity IDA
IDA: Inferred from direct assay
22037414 MGI
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
22037414 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
11369777 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
12404118 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11684016 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12011074 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12404118 MGI
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
31748744 MGI
acts upstream of or within apoptotic process IDA
IDA: Inferred from direct assay
16183742 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
16183742 MGI
involved in execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
24813849 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10588860 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22089168 MGI
involved in extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
31748744 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
15322156 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12404118 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
31748744 MGI
acts upstream of or within hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
15322156 MGI
acts upstream of or within macrophage differentiation IMP
IMP: Inferred from mutant phenotype
15322156 MGI
acts upstream of necroptotic process IGI
IGI: Inferred from genetic interaction
21368763 MGI
acts upstream of or within negative regulation of necroptotic process IGI
IGI: Inferred from genetic interaction
21368763 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
31511692 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
12404118 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9654089 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9654089 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
24813849 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
9837723 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
9729047 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16183742 MGI
involved in protein processing IDA
IDA: Inferred from direct assay
30361383 MGI
involved in proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
32971525 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
30361383 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
31748744 MGI
acts upstream of or within regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
15456877 MGI
involved in regulation of cytokine production IDA
IDA: Inferred from direct assay
32971525 MGI
involved in regulation of innate immune response IDA
IDA: Inferred from direct assay
32971525 MGI
acts upstream of or within regulation of thymocyte apoptotic process IGI
IGI: Inferred from genetic interaction
15456877 MGI
involved in self proteolysis IMP
IMP: Inferred from mutant phenotype
31511692 MGI
Cellular Component GO Annotation Evidence References Source
part of Noc1p-Noc2p complex IMP
IMP: Inferred from mutant phenotype
14657025 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10638761 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12065591 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10638761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp8 Protein Structure

DED_Caspase_8_r1

DED_Caspase_8_r1: cd08333 (2 - 83)

DD

DD: cl14633 (97 - 178)

CASc

CASc: cd00032 (226 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

caspase-8

  • Fas-linked ICE-like protease

Casp8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86835 Caspase-8 (p18) Antibody (YA6528) WB, ICC/IF Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153161 CASP8-IN-1 Inhibitor 98.97% Unkown
HY-RS01965 CASP8 Human Pre-designed siRNA Set A / Unkown
HY-P10146 Ac-LETD-CHO Inhibitor / Unkown
HY-RS01966 Casp8 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01967 Casp8 Rat Pre-designed siRNA Set A / Unkown
HY-RS01968 CASP8AP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp8 NCBI NCBI:841