Ccnd1 - cyclin D1 Gene

Also Known as cD1; CycD1; Cyl-1; PRAD1; bcl-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12443

Summary

Enables cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase activity; and protein kinase binding activity. Involved in negative regulation of epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; gland development; and positive regulation of mammary gland epithelial cell proliferation. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic Cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Apr 2022]

Ccnd1 Products (2)

mRNA Protein Name
NM_001379248.1 NP_001366177.1 G1/S-specific cyclin-D1 isoform 1
NM_007631.3 NP_031657.1 G1/S-specific cyclin-D1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
IDA: Inferred from direct assay
12502791 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12124778 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8534916 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12588994 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19767775 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
16176978 MGI
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
26876175 MGI
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: Inferred from direct assay
16176978 MGI
acts upstream of or within fat cell differentiation IDA
IDA: Inferred from direct assay
12502791 MGI
acts upstream of or within lactation IGI
IGI: Inferred from genetic interaction
11747812 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
10419681 MGI
acts upstream of or within liver regeneration IDA
IDA: Inferred from direct assay
23740243 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
11747812 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
10419681 MGI
acts upstream of mammary gland epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
20075866 MGI
acts upstream of or within mammary gland epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
11747812 MGI
involved in negative regulation of epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
15314168 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
26876175 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15314168 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
26876175 MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
20075866 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12124778 MGI
acts upstream of or within re-entry into mitotic cell cycle IDA
IDA: Inferred from direct assay
12502791 MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
21411630 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
11809706 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
21411630 MGI
part of cyclin D1-CDK4 complex IPI
IPI: Inferred from physical interaction
17948060 MGI
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
12970760 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19531352 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
15314168 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8988060 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G1/S-specific cyclin-D1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0692 Schisandrol B 99.92% Unkown
HY-168664 CPD-39 Degrader 98.06% Unkown
HY-168660 CPD-10 98.59% Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-RS02123 CCND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181131 Anticancer agent 300 / Unkown
HY-181769 Anticancer agent 306 / Unkown
HY-184301 EGFR/HER2-IN-20 / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-183004 NCP26 / Unkown
HY-RS16780 Ccnd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23220 Ccnd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccnd1 NCBI NCBI:595