Ccne1 - cyclin E1 Gene

Also Known as CycE1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12447

Summary

Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spinal cord. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]

Ccne1 Products (1)

mRNA	Protein	Name
NM_007633.2	NP_031659.2	G1/S-specific cyclin-E1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA IDA: Inferred from direct assay	12970171	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12124778	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10500095	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11981756	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA replication initiation	IMP IMP: Inferred from mutant phenotype	12941272	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle	IGI IGI: Inferred from genetic interaction	24586195	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IGI IGI: Inferred from genetic interaction	24586195	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7797074	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12124778	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	12970171	MGI
acts upstream of or within regulation of protein localization	IGI IGI: Inferred from genetic interaction	24586195	MGI
acts upstream of or within telomere maintenance	IGI IGI: Inferred from genetic interaction	24586195	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin E1-CDK2 complex	IDA IDA: Inferred from direct assay	7739547	MGI
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	12970760	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10500095	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
G1/S-specific cyclin-E1

Ccne1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ccne1	Q61457	Cdk1	Mus musculus	P11440	Anti Bait CoIP	19592082
Intra	Ccne1	Q61457	Cdk2	Mus musculus	P97377	Anti Bait CoIP	20150892
Intra	Ccne1	Q61457	Cdk2	Mus musculus	P97377	Anti Bait CoIP	19592082

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ccne1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72964	Cyclin E Protein, Mouse (sf9, His-GST)	Q61457 (M1-E408)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145817A	lunresertib	Inhibitor	99.97%	Phase 2
HY-170442	ECI830	Inhibitor	98.01%	Phase 2
HY-160701	Cirtociclib		99.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175842	CDK2 degrader 7	Degrader	99.51%	Unkown
HY-164827	CDK2 degrader 3	Degrader	99.91%	Unkown
HY-162255	CDK2-IN-23	Inhibitor	99.29%	Unkown
HY-159805	CDK2-IN-31	Inhibitor	98.22%	Unkown
HY-RS02127	CCNE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180485	PROTAC D16-M1P2		/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-175819	PD-166285		/	Unkown
HY-180196	EGFR-IN-187		/	Unkown
HY-180484	PKMYT1-IN-12	Inhibitor	/	Unkown
HY-181004	PKMYT1-IN-13	Inhibitor	/	Unkown
HY-181131	Anticancer agent 300		/	Unkown
HY-184649	CDK2-IN-60	Inhibitor	/	Unkown
HY-186126	CDK2 modulator 1	Modulator	/	Unkown
HY-186127	CCNE1 degrader-1	Degrader	/	Unkown
HY-186132	PROTAC CDK2-pRb degrader-1	Degrader	/	Unkown
HY-RS17273	Ccne1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23727	Ccne1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccne1	NCBI	NCBI:898