CCNE1 - cyclin E1 Gene

Also Known as CCNE; pCCNE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 898

About CCNE1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,811,991-29,824,312 (from NCBI)

This gene has 7 transcripts (splice variants), 234 orthologues, 18 paralogues and is associated with 63 phenotypes. Biased expression in placenta (RPKM 16.5), bone marrow (RPKM 11.3) and 12 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

CCNE1 Products (4)

mRNA	Protein	Name
NM_001238.4	NP_001229.1	G1/S-specific cyclin-E1 isoform 1
NM_001322259.2	NP_001309188.1	G1/S-specific cyclin-E1 isoform 3
NM_001322261.2	NP_001309190.1	G1/S-specific cyclin-E1 isoform 4
NM_001322262.2	NP_001309191.1	G1/S-specific cyclin-E1 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8756624	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23083510	GOA
involved in positive regulation of mesenchymal stem cell proliferation	IMP IMP: Inferred from mutant phenotype	23083510	GOA
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	10500095	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin E1-CDK2 complex	IPI IPI: Inferred from physical interaction	8756624	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16109376	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNE1 Protein Structure

Cyclin_N

Cyclin_C

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
G1/S-specific cyclin-E1

CCNE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCNE1	P24864	GMNC	Homo sapiens	A6NCL1	Y2H Prey Pooling	32296183
Intra	CCNE1	P24864	GMNC	Homo sapiens	A6NCL1	Y2H Array	32296183
Intra	CCNE1	P24864	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	17525332
Intra	CCNE1	P24864	CDKN1A	Homo sapiens	P38936	PLA	25241761
Intra	CCNE1	P24864	CDKN1A	Homo sapiens	P38936	Anti Bait CoIP	8756624
Intra	CCNE1	P24864	CDKN1A	Homo sapiens	P38936	Pull Down	8756624
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Anti Tag CoIP	16223725
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Anti Bait CoIP	8756624
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Anti Bait CoIP	17254967
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Anti Bait CoIP	19470470
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Pull Down	8756624
Intra	CCNE1	P24864	CDK2	Homo sapiens	P24941	Anti Bait CoIP	10330164
Intra	CCNE1	P24864	CDKN1B	Homo sapiens	P46527	Pull Down	8756624
Intra	CCNE1	P24864	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17254966
Intra	CCNE1	P24864	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	19470470
Intra	CCNE1	P24864	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17254967
Intra	CCNE1	P24864	CDKN1B	Homo sapiens	P46527	PLA	25241761
Intra	CCNE1	P24864	UHRF2	Homo sapiens	Q96PU4	Anti Tag CoIP	21952639
Cross	CCNE1	P24864	AKAP8	Canis familiaris	Q5VK71	Anti Tag CoIP	16721056

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCNE1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72963	Cyclin E Protein, Human (sf9, His-GST)	P24864 (M1-A410)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74214	Cyclin E Protein, Human (sf9)	P24864 (M1-A410)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74257	CDK1-CCNE1 Heterodimer Protein, Human (Inactive, sf9, His-GST)	NP_001777.1 (M1-M297)& NP_001229.1 (M1-A410)	≥ 90%, as determined by reducing SDS-PAGE.

CCNE1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80100	Cyclin E1 Antibody (YA483)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80635	Cyclin E1 Antibody	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P80807	Phospho-Cyclin E1 (Thr395) Antibody	WB	Human
HY-P84205	Cyclin E1 Antibody (YA3902)	IHC-P, FC, ELISA	Human
HY-P84205A	Cyclin E1 Antibody (YA3902)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86624	Cyclin E1 Antibody (YA6316)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Senile Angioma	Senile Hemangioma Senile Naevus Of Skin
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Endometrial Serous Adenocarcinoma	Uterine Serous Carcinoma Uterine Corpus Serous Adenocarcinoma Uterine Papillary Serous Carcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Uterine Body Mixed Cancer	Malignant Mixed Tumor Of Corpus Uteri Malignant Mixed Tumor, Not Otherwise Specified
Fallopian Tube Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Fallopian Tube Fallopian Tube Endometrioid Cancer Fallopian Tube Endometrioid Neoplasm Fallopian Tube Endometrioid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145817A	lunresertib	Inhibitor	99.97%	Phase 2
HY-170442	ECI830	Inhibitor	98.01%	Phase 2
HY-160701	Cirtociclib		99.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175842	CDK2 degrader 7	Degrader	99.51%	Unkown
HY-164827	CDK2 degrader 3	Degrader	99.91%	Unkown
HY-162255	CDK2-IN-23	Inhibitor	99.29%	Unkown
HY-159805	CDK2-IN-31	Inhibitor	98.22%	Unkown
HY-RS02127	CCNE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180485	PROTAC D16-M1P2	Degrader	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-175819	PD-166285		/	Unkown
HY-180196	EGFR-IN-187		/	Unkown
HY-180484	PKMYT1-IN-12	Inhibitor	/	Unkown
HY-181004	PKMYT1-IN-13	Inhibitor	/	Unkown
HY-181131	Anticancer agent 300		/	Unkown
HY-184649	CDK2-IN-60	Inhibitor	/	Unkown
HY-186126	CDK2 modulator 1	Modulator	/	Unkown
HY-186127	CCNE1 degrader-1	Degrader	/	Unkown
HY-186132	PROTAC CDK2-pRb degrader-1	Degrader	/	Unkown
HY-RS17273	Ccne1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23727	Ccne1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCNE1	MGD	MGI:88316
Felis catus	CCNE1	VGNC	VGNC:60557
Rattus norvegicus	CCNE1	RGD	RGD:2294
Canis familiaris	CCNE1	VGNC	VGNC:38898
Macaca mulatta	CCNE1	VGNC	VGNC:70727
Bos taurus	CCNE1	VGNC	VGNC:26966
Others	CCNE1	NCBI