Ccne2 - cyclin E2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12448

Summary

Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and regulation of protein localization. Part of cyclin E2-CDK2 complex. Is expressed in several structures, including cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Apr 2022]

Ccne2 Products (3)

mRNA Protein Name
NM_001037134.2 NP_001032211.1 G1/S-specific cyclin-E2 isoform 1
NM_001282943.1 NP_001269872.1 G1/S-specific cyclin-E2 isoform 1
NM_009830.3 NP_033960.1 G1/S-specific cyclin-E2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
IDA: Inferred from direct assay
9840927 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA replication initiation IMP
IMP: Inferred from mutant phenotype
12941272 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IGI
IGI: Inferred from genetic interaction
24586195 MGI
acts upstream of or within homologous chromosome pairing at meiosis IGI
IGI: Inferred from genetic interaction
24586195 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
9840927 MGI
acts upstream of or within regulation of protein localization IGI
IGI: Inferred from genetic interaction
24586195 MGI
acts upstream of or within telomere maintenance IGI
IGI: Inferred from genetic interaction
24586195 MGI
Cellular Component GO Annotation Evidence References Source
part of cyclin E2-CDK2 complex IDA
IDA: Inferred from direct assay
7739547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G1/S-specific cyclin-E2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02128 CCNE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22420 Ccne2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28943 Ccne2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccne2 NCBI NCBI:9134