CCNE2 - cyclin E2 Gene

Also Known as CYCE2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9134

About CCNE2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,880,224-94,896,693 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 18 paralogues. Broad expression in testis (RPKM 6.8), bone marrow (RPKM 6.2) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

CCNE2 Products (1)

mRNA	Protein	Name
NM_057749.3	NP_477097.1	G1/S-specific cyclin-E2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9840943	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin E2-CDK2 complex	IPI IPI: Inferred from physical interaction	15232106	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNE2 Protein Structure

Cyclin_N

Cyclin_C

0
100
200
300
404 a.a.

Protein Preferred Names	Protein Names
G1/S-specific cyclin-E2

CCNE2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCNE2	O96020	CDK3	Homo sapiens	Q00526	Y2H	9840943
Intra	CCNE2	O96020	CDKN1A	Homo sapiens	P38936	GMS	24358021
Intra	CCNE2	O96020	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	28514442
Intra	CCNE2	O96020	CDK2	Homo sapiens	P24941	Anti Bait CoIP	9840943
Intra	CCNE2	O96020	CDK2	Homo sapiens	P24941	GMS	24358021
Intra	CCNE2	O96020	CDK2	Homo sapiens	P24941	Y2H	9840943
Intra	CCNE2	O96020	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CCNE2	O96020	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CCNE2	O96020	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CCNE2	O96020	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	9840943
Intra	CCNE2	O96020	CDKN1B	Homo sapiens	P46527	GMS	24358021
Intra	CCNE2	O96020	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CCNE2	O96020	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CCNE2	O96020	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CCNE2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82849	Cyclin E2 Antibody (YA2594)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P82849A	Cyclin E2 Antibody (YA2594)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02128	CCNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22420	Ccne2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28943	Ccne2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCNE2	MGD	MGI:1329034
Canis familiaris	CCNE2	VGNC	VGNC:54109
Felis catus	CCNE2	VGNC	VGNC:60558
Macaca mulatta	CCNE2	VGNC	VGNC:70728
Bos taurus	CCNE2	VGNC	VGNC:26967
Rattus norvegicus	CCNE2	RGD	RGD:1307783
Others	CCNE2	NCBI