Ccr6 - chemokine (C-C motif) receptor 6 Gene

Also Known as CCR-6; KY411; Cmkbr6; CC-CKR-6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12458

About Ccr6

Chromosome 17: 8,454,875-8,475,973 forward strand.GRCm39:CM001010.3

This gene has 9 transcripts (splice variants), 299 orthologues, 25 paralogues and is associated with 58 phenotypes. Biased expression in spleen adult (RPKM 9.8), mammary gland adult (RPKM 4.1) and 5 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in several processes, including immune system development; leukocyte migration; and regulation of cell motility. Located in external side of plasma membrane; sperm plasma membrane; and sperm principal piece. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and retina. Orthologous to human CCR6 (C-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Ccr6 Products (7)

mRNA Protein Name
NM_001190335.1 NP_001177264.1 C-C chemokine receptor type 6 isoform A
NM_001190334.1 NP_001177263.1 C-C chemokine receptor type 6 isoform A
NM_001190336.1 NP_001177265.1 C-C chemokine receptor type 6 isoform A
NM_001190333.1 NP_001177262.1 C-C chemokine receptor type 6 isoform A
NM_009835.4 NP_033965.1 C-C chemokine receptor type 6 isoform A
NM_001190338.1 NP_001177267.1 C-C chemokine receptor type 6 isoform B
NM_001190337.1 NP_001177266.1 C-C chemokine receptor type 6 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine binding IDA
IDA: Inferred from direct assay
20068036 MGI
enables C-C chemokine receptor activity IDA
IDA: Inferred from direct assay
20068036 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9862452 MGI
Biological Process GO Annotation Evidence References Source
involved in DN2 thymocyte differentiation IMP
IMP: Inferred from mutant phenotype
24638065 MGI
involved in DN3 thymocyte differentiation IMP
IMP: Inferred from mutant phenotype
24638065 MGI
involved in T cell migration IDA
IDA: Inferred from direct assay
24638065 MGI
involved in chemotaxis IDA
IDA: Inferred from direct assay
20068036 MGI
involved in isotype switching to IgA isotypes IMP
IMP: Inferred from mutant phenotype
27174992 MGI
involved in leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
19050256 MGI
involved in lymphocyte migration IMP
IMP: Inferred from mutant phenotype
27174992 MGI
involved in positive regulation of flagellated sperm motility involved in capacitation IDA
IDA: Inferred from direct assay
23765988 MGI
involved in regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
19050256 MGI
NOT involved in regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
19050256 MGI
involved in thymocyte migration IDA
IDA: Inferred from direct assay
24638065 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23620790 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23034280 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
23765988 MGI
located in sperm plasma membrane IDA
IDA: Inferred from direct assay
23765988 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
23765988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr6 Protein Structure

7tmA_CCR6

7tmA_CCR6: cd15172 (38 - 65)

7tmA_CCR6

7tmA_CCR6: cd15172 (38 - 318)

7tmA_CCR6

7tmA_CCR6: cd15172 (72 - 97)

7tmA_CCR6

7tmA_CCR6: cd15172 (109 - 139)

7tmA_CCR6

7tmA_CCR6: cd15172 (153 - 175)

7tmA_CCR6

7tmA_CCR6: cd15172 (202 - 231)

7tmA_CCR6

7tmA_CCR6: cd15172 (238 - 268)

7tmA_CCR6

7tmA_CCR6: cd15172 (286 - 311)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148531 PF-07054894 Inhibitor 99.15% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151435 CCR6 antagonist 1 Antagonist 99.30% Unkown
HY-112701 CCR6 inhibitor 1 Inhibitor 99.60% Unkown
HY-162495 IDOR-1117-2520 Antagonist 99.94% Unkown
HY-162495A (S)-IDOR-1117-2520 Antagonist 99.47% Unkown
HY-176980 CCR6 antagonist 4 Antagonist / Unkown
HY-176979 CCR6 antagonist 3 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr6 NCBI NCBI:1235