Cd2 - CD2 antigen Gene

Also Known as Ly37; LFA-2; Ly-37

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12481

Summary

Enables identical protein binding activity. Predicted to be involved in T cell activation; heterotypic cell-cell adhesion; and positive regulation of cytokine production. Located in several cellular components, including cell-cell junction; cytoplasmic side of plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd2 Products (1)

mRNA Protein Name
NM_013486.2 NP_038514.1 T-cell surface antigen CD2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
1383383 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1383383 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
1383383 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8125140 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
1383383 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
1383383 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface antigen CD2

  • LFA-3 receptor

  • T-cell surface antigen T11/Leu-5

  • lymphocyte antigen 37

Recombinant Cd2 Proteins

Cat. No. Product Name Accession Purity
HY-P74323 CD2 Protein, Mouse (HEK293, His) NP_038514.1 (R23-S203, M128V, N175S, M192J) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-158109 M3554 Inhibitor 98.74% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99904 Siplizumab Inhibitor 99.83% Phase 2

Pre-clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990868 Anti-CD2 Antibody (CB.219) Inhibitor 95.50% Unkown
HY-P991543 BTI-322 Inhibitor 98.15% Unkown
HY-P990286 Anti-Rat CD2 Antibody (OX-34) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd2 NCBI NCBI:914