Scarb2 - scavenger receptor class B, member 2 Gene

Also Known as LGP85; Cd36l2; LIMP-2; MLGP85; LIMP II; 9330185J12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12492

Summary

This gene encodes a CD36-like type III Transmembrane Glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]

Scarb2 Products (1)

mRNA	Protein	Name
NM_007644.4	NP_031670.1	lysosome membrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	18022370	MGI
enables cholesterol binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	18022370	MGI
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27789271	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	29199275	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	27789271	MGI
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	29199275	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in aminophospholipid transport	IDA IDA: Inferred from direct assay	29199275	MGI
acts upstream of or within endosome to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	16901941	MGI
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	18022370	MGI
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	29199275	MGI
involved in regulation of carbohydrate catabolic process	IMP IMP: Inferred from mutant phenotype	18022370	MGI
involved in regulation of glucosylceramidase activity	IMP IMP: Inferred from mutant phenotype	25316793	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16901941	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endocytic vesicle membrane	IDA IDA: Inferred from direct assay	29199275	MGI
located in lysosomal lumen	IDA IDA: Inferred from direct assay	18022370	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18022370	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29199275	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysosome membrane protein 2	85 kDa lysosomal membrane sialoglycoprotein CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 lysosome membrane protein II

Recombinant Scarb2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72515	SCARB2/LIMP-2 Protein, Mouse (HEK293, His)	O35114 (R27-T432)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72895	CD36 Protein, Mouse (HEK293, His)	Q08857 (G30-K439)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12489	SCARB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18568	Scarb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25052	Scarb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scarb2	NCBI	NCBI:950