Cfh - complement component factor h Gene

Also Known as NOM; Sas1; Mud-1; Sas-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12628

Summary

Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within several processes, including animal organ development; complement activation; and vasculature development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement Factor H). [provided by Alliance of Genome Resources, Apr 2022]

Cfh Products (1)

mRNA Protein Name
NM_009888.3 NP_034018.2 complement factor H precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables complement component C3b binding IPI
IPI: Inferred from physical interaction
16023208 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
16023208 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23487775 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ATP metabolic process IMP
IMP: Inferred from mutant phenotype
26149919 MGI
acts upstream of or within activation of membrane attack complex IMP
IMP: Inferred from mutant phenotype
20813971 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
28057640 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cellular response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within complement activation IDA
IDA: Inferred from direct assay
19411110 MGI
acts upstream of or within complement activation IGI
IGI: Inferred from genetic interaction
20702729 MGI
acts upstream of or within complement activation IMP
IMP: Inferred from mutant phenotype
15574507 MGI
acts upstream of or within complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
27564415 MGI
acts upstream of or within negative effect complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within complement activation, alternative pathway IMP
IMP: Inferred from mutant phenotype
27564415 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
28057640 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
15574507 MGI
acts upstream of or within glomerulus development IGI
IGI: Inferred from genetic interaction
16769899 MGI
acts upstream of or within glomerulus development IMP
IMP: Inferred from mutant phenotype
15574507 MGI
acts upstream of or within immune complex clearance IGI
IGI: Inferred from genetic interaction
20702729 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
19541934 MGI
acts upstream of or within immunoglobulin mediated immune response IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
26149919 MGI
acts upstream of or within inflammatory response to wounding IGI
IGI: Inferred from genetic interaction
21148255 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
16769899 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17517971 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: Inferred from mutant phenotype
30705315 MGI
acts upstream of or within mitochondrial gene expression IMP
IMP: Inferred from mutant phenotype
26149919 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
30705315 MGI
acts upstream of or within monocyte aggregation IMP
IMP: Inferred from mutant phenotype
28228282 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
29070671 MGI
acts upstream of or within neutrophil homeostasis IGI
IGI: Inferred from genetic interaction
16769899 MGI
acts upstream of or within organ or tissue specific immune response IGI
IGI: Inferred from genetic interaction
20702729 MGI
acts upstream of or within organelle localization IMP
IMP: Inferred from mutant phenotype
17921253 MGI
acts upstream of or within photoreceptor cell differentiation IMP
IMP: Inferred from mutant phenotype
26149919 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
28057640 MGI
acts upstream of or within regulation of complement activation IMP
IMP: Inferred from mutant phenotype
18947875 MGI
acts upstream of or within response to cytokine IDA
IDA: Inferred from direct assay
19299737 MGI
acts upstream of or within response to dietary excess IMP
IMP: Inferred from mutant phenotype
25991857 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
28057640 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
17921253 MGI
acts upstream of or within positive effect retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
30705315 MGI
acts upstream of or within retinal pigment epithelium development IMP
IMP: Inferred from mutant phenotype
23844226 MGI
acts upstream of or within retinal rod cell development IMP
IMP: Inferred from mutant phenotype
17921253 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
28057640 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
28057640 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
17517971 MGI
involved in visual perception IMP
IMP: Inferred from mutant phenotype
17921253 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19299737 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19299737 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
19411110 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17028856 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
19299737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement factor H

  • complement factor H related protein 3A4/5G4

  • protein beta-1-H

Recombinant Cfh Proteins

Cat. No. Product Name Accession Purity
HY-P7830 Complement factor H/CFH Protein, Mouse (HEK293, His) E9Q8I0 (S875-V1252) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74232 Complement factor H/CFH Protein, Mouse (HEK293, Fc) E9Q8I0/NP_034018.2 (S875-V1252) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991954 GT103 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02561 CFH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17522 Cfh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23978 Cfh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfh NCBI NCBI:3075