Socs1 - suppressor of cytokine signaling 1 Gene

Also Known as JAB; Cish1; Cish7; SSI-1; SOCS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12703

Summary

Enables kinase inhibitor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell differentiation and positive regulation of CD4-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of Insulin Receptor signaling pathway; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including adipose tissue; gut; hemolymphoid system gland; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder Cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1). [provided by Alliance of Genome Resources, Apr 2022]

Socs1 Products (2)

mRNA Protein Name
NM_001271603.1 NP_001258532.1 suppressor of cytokine signaling 1
NM_009896.2 NP_034026.1 suppressor of cytokine signaling 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase inhibitor activity IDA
IDA: Inferred from direct assay
9202126 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9202126 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
11854514 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
9202126 MGI
acts upstream of or within cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11606785 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
16127460 MGI
involved in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
24880459 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
15169905 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
11371356 MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
9202127 MGI
involved in positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
24880459 MGI
acts upstream of or within regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
21606371 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15169905 MGI
acts upstream of or within regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
21606371 MGI
acts upstream of or within regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
21606371 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of cytokine signaling 1

  • JAK2-binding protein

  • STAT-induced STAT inhibitor 1

  • cytokine inducible SH2-containing protein 1

  • cytokine inducible SH2-containing protein 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10373 pJAK2(1001-1013) 99.89% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-114495 Caerulomycin A Inhibitor 98.0% Unkown
HY-118828B 12-Oxo phytodienoic acid (≥90%) 92.2% Unkown
HY-181653 PROTAC SKP2 Degrader-1 99.91% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-RS17712 Socs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124665 LMP-420 / Unkown
HY-172535 Lipid OA2 dihydrochloride / Unkown
HY-N20661 Albaconol / Unkown
HY-RS13552 SOCS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24177 Socs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Socs1 NCBI NCBI:8651