ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

Also Known as FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 128

About ADH5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,070,978-99,088,788 (from NCBI)

This gene has 13 transcripts (splice variants), 391 orthologues, 17 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues.

Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

ADH5 Products (1)

mRNA Protein Name
NM_000671.4 NP_000662.3 alcohol dehydrogenase class-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables fatty acid binding IDA
IDA: Inferred from direct assay
8460164 GOA
enables formaldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
8460164 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
6375718 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in fatty acid omega-oxidation IDA
IDA: Inferred from direct assay
16081420 GOA
involved in response to redox state IDA
IDA: Inferred from direct assay
8460164 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH5 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (33 - 159)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (202 - 323)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

alcohol dehydrogenase class-3

  • S-(hydroxymethyl)glutathione dehydrogenase

  • S-nitrosoglutathione reductase

  • alcohol dehydrogenase (class III), chi polypeptide

  • alcohol dehydrogenase class chi chain

  • alcohol dehydrogenase class-III

  • epididymis secretory sperm binding protein Li 60p

  • formaldehyde dehydrogenase

  • glutathione-dependent formaldehyde dehydrogenase

ADH5 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82253 ADH5 Antibody (YA1998) WB, IHC-P, IP Human
HY-P82253A ADH5 Antibody (YA1998)(PBS only) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Contact Dermatitis

  • Contact Dermatitis/Eczema

  • Contact Eczema

  • Dermatitis Venenata

  • Dermatitis, Venenata

  • Dermatitis Contact

  • Dermatitis, Contact
Thyroid Dyshormonogenesis 3

  • TDH3

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

  • Thyroid Hormonogenesis, Genetic Defect In, 3

  • Genetic Defect In Thyroid Hormonogenesis 3

  • Chdh3

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

  • Genetic Defect In Thyroid Hormonogenesis Type 3
Familial Thyroid Dyshormonogenesis

  • Thyroid Dyshormonogenesis

  • Familial Dyshormonogenetic Goiter
Proliferative Type Fibrocystic Change Of Breast

  • Fibrocystic Change, Proliferative Type With Atypia

  • Fibrocystic Disease, Proliferative Type With Atypia

  • Proliferating Lesion Of Breast Without Atypia

  • Proliferating Lesion Of The Breast Without Atypia

  • Proliferative Fibrocystic Change

  • Breast Fibrocystic Change, Proliferative Type
Breast Intraductal Proliferative Lesion

  • Intraductal Proliferative Lesion

  • Intraductal Proliferative Lesion Of The Breast
Pharyngitis

  • Acute Pharyngitis

  • Chronic Pharyngitis

  • Acute Sore Throat

  • Chronic Sore Throat

  • Persistent Sore Throat

  • Pharyngeal Diseases

  • Chronic Pharyn/Nasopharyngitis

  • Chronic Pharyngitis And Nasopharyngitis

  • Inflamed Throat

  • Pharyngeal Disease

  • Pharyngeal Disorder

  • Pharyngitis - Acute

  • Sore Throat - Chronic

  • Acute Pharyngitis Nos

  • Acute Sore Throat Nos

  • Acute Throat Inflammation

  • Infective Pharyngitis

  • Infection Of Pharynx

  • Acute Infective Pharyngitis

  • Acute Infective Pharyngitis Nos

  • Acute Pharyngeal Inflammation

  • Inflammation Of The Throat

  • Throat Inflammation

  • Throat Infection

  • Putrid Pharyngitis

  • Pharyngeal Inflammation

  • Pharyngitis Nos

  • Chronic Throat Pain

  • Throat Catarrh
Congenital Hypothyroidism

  • Cretinism

  • Neonatal Hypothyroidism

  • Ch

  • Cht

  • Congenital Myxedema

  • Myxedema, Congenital

  • Endemic Cretinism

  • Congenital Iodine-Deficiency Syndrome

  • Fetal Iodine Deficiency Syndrome

  • Congenital Iodine-Deficiency Hypothyroidism Nos
Substance Dependence
Amed Syndrome, Digenic

  • Amed Syndrome

  • AMEDS

  • Bone Marrow Failure Syndrome 7, Digenic

  • Bmfs7

  • Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcohol Dependence, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Focal Dermal Hypoplasia

  • Goltz Syndrome

  • Goltz-Gorlin Syndrome

  • FDH

  • FODH

  • Dhof

  • Goltz Gorlin Syndrome

  • Hypoplasia, Dermal, Focal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00370 ADH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00371 Adh5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00372 Adh5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00373 ADH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADH5 MGD MGI:87929