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TRIM43 - tripartite motif containing 43 Gene

Also Known as TRIM43A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 129868

About TRIM43

This gene has 1 transcript (splice variant), 93 orthologues and 80 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM43 Products (1)

mRNA	Protein	Name
NM_138800.3	NP_620155.1	tripartite motif-containing protein 43

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM43 Protein Structure

zf-C3HC4_4

SPRY

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 43

TRIM43 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM43	Q96BQ3	GRB7	Homo sapiens	Q14451-3	Y2H Array	32296183
Intra	TRIM43	Q96BQ3	GRB7	Homo sapiens	Q14451-3	Y2H Prey Pooling	32296183
Intra	TRIM43	Q96BQ3	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	TRIM43	Q96BQ3	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	TRIM43	Q96BQ3	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	TRIM43	Q96BQ3	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	TRIM43	Q96BQ3	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	TRIM43	Q96BQ3	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	TRIM43	Q96BQ3	ENOX1	Homo sapiens	Q8TC92	Validated Y2H	25416956
Intra	TRIM43	Q96BQ3	ENOX1	Homo sapiens	Q8TC92	Y2H Prey Pooling	32296183
Intra	TRIM43	Q96BQ3	ENOX1	Homo sapiens	Q8TC92	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Facioscapulohumeral Muscular Dystrophy 1	Facioscapulohumeral Muscular Dystrophy Fshd Landouzy-Dejerine Muscular Dystrophy Muscular Dystrophy, Facioscapulohumeral FSHD1 Fshd1a Muscular Dystrophy, Facioscapulohumeral, Type 1a Facioscapulohumeral Muscular Dystrophy Type 1a Fsh Muscular Dystrophy Facioscapulohumeral Muscular Dystrophy 1a Facioscapulohumeral Atrophy Facioscapulohumeral Myopathy Muscular Dystrophy, Facioscapulohumeral, Type 1 Facioscapulohumeral Muscular Dystrophy Type 1 Landouzy Dejerine Muscular Dystrophy Muscular Dystrophy, Landouzy-Dejerine Fshmd1a Facio-Scapulo-Humeral Dystrophy Facioscapulohumeral Type Progressive Muscular Dystrophy Facioscapuloperoneal Muscular Dystrophy Facioscapulohumeral Dystrophy Fsh Dystrophy Landouzy-Dejerine Dystrophy Landouzy-Dejerine Myopathy Fmd Facioscapulohumeral Muscular Dystrophy-1a Muscular Dystrophy Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral, Type 1 Landouzy-Dejerine Disease Landouzy-Déjerine Atrophy Facioscapulohumeral Muscle Dystrophy Fmd - [Facioscapulohumeral Muscular Dystrophy] Fsh - [Facioscapulohumeral Muscular Dystrophy] Fshd - [Facioscapulohumeral Muscular Dystrophy] Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic	Facioscapulohumeral Muscular Dystrophy 2 FSHD2 Fshd1b Facioscapulohumeral Muscular Dystrophy 1b Fshd2, Digenic Muscular Dystrophy, Facioscapulohumeral, Type 2 Muscular Dystrophy, Facioscapulohumeral, Type 1b Fascioscapulohumeral Muscular Dystrophy 2, Digenic Facioscapulohumeral Muscular Dystrophy Type 2 Digenic Facioscapulohumeral Muscular Dystrophy Digenic Fshd2 Facioscapulohumeral Muscular Dystrophy Type 1b Dystrophy, Muscular, Facioscapulohumeral, Type 2
Digenic Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15047	TRIM43 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM43	RGD	RGD:1561074