ENOX1 - ecto-NOX disulfide-thiol exchanger 1 Gene

Also Known as CNOX; PIG38; cCNOX; bA64J21.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55068

About ENOX1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,213,130-43,786,972 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.9), brain (RPKM 1.3) and 19 other tissues.

Summary

The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the Other is at its lowest. [provided by RefSeq, Dec 2016]

ENOX1 Products (12)

mRNA Protein Name
NM_001127615.3 NP_001121087.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001242863.3 NP_001229792.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347963.2 NP_001334892.1 ecto-NOX disulfide-thiol exchanger 1 isoform a
NM_001347964.2 NP_001334893.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347965.2 NP_001334894.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347966.2 NP_001334895.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347967.2 NP_001334896.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347968.2 NP_001334897.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347969.2 NP_001334898.1 ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347970.2 NP_001334899.1 ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_001347971.2 NP_001334900.1 ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_017993.5 NP_060463.2 ecto-NOX disulfide-thiol exchanger 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables NADH dehydrogenase activity IDA
IDA: Inferred from direct assay
19055324 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein disulfide isomerase activity IDA
IDA: Inferred from direct assay
19055324 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOX1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (144 - 199)

  • 0
  • 100
  • 200
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  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

ecto-NOX disulfide-thiol exchanger 1

  • candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase

ENOX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENOX1 Q8TC92 ENOX2 Homo sapiens Q16206-2
Y2H Prey Pooling
25416956
Intra
ENOX1 Q8TC92 ENOX2 Homo sapiens Q16206-2
Validated Y2H
25416956
Intra
ENOX1 Q8TC92 ENOX2 Homo sapiens Q16206-2
Y2H Array
25416956
Intra
ENOX1 Q8TC92 TRIM43 Homo sapiens Q96BQ3
Validated Y2H
32296183
Intra
ENOX1 Q8TC92 TRIM43 Homo sapiens Q96BQ3
Y2H Array
25416956
Intra
ENOX1 Q8TC92 TRIM43 Homo sapiens Q96BQ3
Y2H Prey Pooling
25416956
Intra
ENOX1 Q8TC92 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
ENOX1 Q8TC92 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
ENOX1 Q8TC92 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
ENOX1 Q8TC92 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
Intra
ENOX1 Q8TC92 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypocalcemia, Autosomal Dominant 2

  • Autosomal Dominant Hypocalcemia 2

  • HYPOC2

  • Hypocalcemia, Autosomal Dominant, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04384 ENOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ENOX1 VGNC VGNC:40371
Mus musculus ENOX1 MGD MGI:2444896
Bos taurus ENOX1 VGNC VGNC:28502
Macaca mulatta ENOX1 VGNC VGNC:72110
Felis catus ENOX1 VGNC VGNC:61869
Rattus norvegicus ENOX1 RGD RGD:1306118
Others ENOX1 NCBI