Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

Also Known as Cpn2; ALDOS; Cyp11b; Cyp11b-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13072

Summary

Enables steroid 11-beta-monooxygenase activity. Acts upstream of or within several processes, including aldosterone biosynthetic process; drinking behavior; and regulation of systemic arterial blood pressure by hormone. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B2 (Cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b2 Products (1)

mRNA Protein Name
NM_009991.4 NP_034121.4 cytochrome P450 11B2, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables steroid 11-beta-monooxygenase activity IDA
IDA: Inferred from direct assay
1686470 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aldosterone biosynthetic process IDA
IDA: Inferred from direct assay
1686470 MGI
acts upstream of or within drinking behavior IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within monoatomic ion homeostasis IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within regulation of blood volume by renal aldosterone IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
IMP: Inferred from mutant phenotype
16118390 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 11B2, mitochondrial

  • aldosterone synthase

  • aldosterone-synthesizing enzyme

  • corticosterone 18-monooxygenase, CYP11B2

  • cytochrome P-450Aldo

  • cytochrome P-450C18

  • cytochrome P450C11

  • steroid 11-beta-hydroxylase, CYP11B2

  • steroid 18-hydroxylase

  • steroid-11-beta-hydroxylase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.82% Yes
HY-16276A Osilodrostat phosphate Inhibitor 98.83% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19833 Lapiteronel Inhibitor 98.51% Phase 2
HY-113986 Dexfadrostat Inhibitor 98.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113151 18-Oxocortisol Antagonist 99.05% Unkown
HY-163689 Vicadrostat Inhibitor 98.67% Unkown
HY-W002108 3,4-Dihydroquinolin-2(1H)-one ≥95.0% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% Unkown
HY-113986C Dexfadrostat hydrochloride Inhibitor / Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-RS03436 CYP11B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162574 CYP11B2-IN-2 Inhibitor / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17177 Cyp11b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23627 Cyp11b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11b2 NCBI NCBI:1585