Cd55 - CD55 molecule, decay accelerating factor for complement Gene

Also Known as Daf; Daf1; Daf-GPI; GPI-DAF

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 13136

Summary

This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]

Cd55 Products (3)

mRNA Protein Name
NM_001404959.1 NP_001391888.1 complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein
NM_001404960.1 NP_001391889.1 complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein
NM_010016.4 NP_034146.2 complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within regulation of complement activation, classical pathway IMP
IMP: Inferred from mutant phenotype
9892684 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18947875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement decay-accelerating factor, GPI-anchored

  • CD55 antigen

  • Cromer blood group

  • GPI anchor addition signal

  • complement-glycosylphosphatidylinositol

  • decay accelerating factor 1

Recombinant Cd55 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75655 CD55/DAF Protein, Mouse (HEK293, His) Q61475 (D35-T361) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-N9481 Lipoteichoic acid / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02255 CD55 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16836 Cd55 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23278 Cd55 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P991962 Anti-CD55 Antibody Inhibitor 99.76% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Cd55 NCBI NCBI:1604