Cd55 - CD55 molecule, decay accelerating factor for complement Gene

Also Known as Daf; Daf1; Daf-GPI; GPI-DAF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13136

Summary

This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]

Cd55 Products (3)

mRNA Protein Name
NM_001404959.1 NP_001391888.1 complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein
NM_001404960.1 NP_001391889.1 complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein
NM_010016.4 NP_034146.2 complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of complement activation, classical pathway IMP
IMP: Inferred from mutant phenotype
9892684 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18947875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement decay-accelerating factor, GPI-anchored

  • CD55 antigen

  • Cromer blood group

  • GPI anchor addition signal

  • complement-glycosylphosphatidylinositol

  • decay accelerating factor 1

Recombinant Cd55 Proteins

Cat. No. Product Name Accession Purity
HY-P75655 CD55/DAF Protein, Mouse (HEK293, His) Q61475 (D35-T361) ≥ 90%, as determined by reducing SDS-PAGE.

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd55 NCBI NCBI:1604