Asap1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain1 Gene

Also Known as PAP; s19; DEF-1; Ddef1; mKIAA1249

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13196

Summary

Enables GTPase activator activity; SH3 domain binding activity; and phospholipid binding activity. Acts upstream of or within negative regulation of dendritic spine development; positive regulation of membrane tubulation; and positive regulation of podosome assembly. Located in cell projection membrane; dendritic spine; and podosome. Is active in cytosol and plasma membrane. Is expressed in several structures, including gonad; limb; long bone; perichondrium; and thoracic duct. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Asap1 Products (6)

mRNA Protein Name
NM_001276461.2 NP_001263390.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b
NM_001276462.2 NP_001263391.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c
NM_001276463.2 NP_001263392.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d
NM_001276467.2 NP_001263396.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e
NM_001411185.1 NP_001398114.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform f
NM_010026.4 NP_034156.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
10734117 MGI
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
10734117 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
10734117 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
16431365 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9819391 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of dendritic spine development IDA
IDA: Inferred from direct assay
23050017 MGI
acts upstream of or within positive regulation of membrane tubulation IDA
IDA: Inferred from direct assay
16431365 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
23050017 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
23050017 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
23050017 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23050017 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23050017 MGI
located in podosome IDA
IDA: Inferred from direct assay
21352810 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

  • 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein

  • 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein

  • ADP-ribosylation factor-directed GTPase-activating protein 1

  • ARF GTPase-activat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01055 ASAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20858 Asap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27373 Asap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asap1 NCBI NCBI:50807