Dnase1l3 - deoxyribonuclease 1-like 3 Gene

Also Known as Lsd; Dhp2; DNasegamma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13421

Summary

Enables Endonuclease activity. Involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Acts upstream of or within apoptotic DNA fragmentation and programmed cell death involved in cell development. Located in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1 like 3). [provided by Alliance of Genome Resources, Apr 2022]

Dnase1l3 Products (1)

mRNA Protein Name
NM_007870.3 NP_031896.3 deoxyribonuclease gamma precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endonuclease activity IDA
IDA: Inferred from direct assay
12050166 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA catabolic process IDA
IDA: Inferred from direct assay
29191910 MGI
acts upstream of or within apoptotic DNA fragmentation IDA
IDA: Inferred from direct assay
12050166 MGI
involved in neutrophil activation involved in immune response IDA
IDA: Inferred from direct assay
29191910 MGI
acts upstream of or within programmed cell death involved in cell development IDA
IDA: Inferred from direct assay
12050166 MGI
involved in regulation of acute inflammatory response IDA
IDA: Inferred from direct assay
29191910 MGI
involved in regulation of neutrophil mediated cytotoxicity IDA
IDA: Inferred from direct assay
29191910 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12050166 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxyribonuclease gamma

  • DNase I homolog protein DHP2

  • DNase I-like 3

  • DNase gamma

  • LS-DNase

  • deoxyribonuclease I-like 3

  • liver and spleen DNase

  • macrophage specific DNase I

Recombinant Dnase1l3 Proteins

Cat. No. Product Name Accession Purity
HY-P790035 DNase1L3 Protein, Mouse (His) O55070 (L26-S310) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03897 DNASE1L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18729 Dnase1l3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25216 Dnase1l3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnase1l3 NCBI NCBI:1776