Dscam - DS cell adhesion molecule Gene

Also Known as 4932410A21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13508

Summary

Enables netrin receptor binding activity and protein tyrosine kinase binding activity. Involved in generation of neurons; negative regulation of cell adhesion; and netrin-activated signaling pathway. Acts upstream of or within dendrite morphogenesis; locomotory behavior; and post-embryonic retina morphogenesis in camera-type eye. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Is expressed in several structures, including central nervous system; peripheral nervous system; sensory organ; skin; and testis. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

Dscam Products (1)

mRNA	Protein	Name
NM_031174.4	NP_112451.1	cell adhesion molecule DSCAM precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables netrin receptor binding	IPI IPI: Inferred from physical interaction	22685302	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18585357	MGI
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	22685302	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in axon guidance	IDA IDA: Inferred from direct assay	22685302	MGI
involved in axon guidance	IGI IGI: Inferred from genetic interaction	22685302	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18216855	MGI
involved in dendrite self-avoidance	IMP IMP: Inferred from mutant phenotype	19945391	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	18216855	MGI
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	19945391	MGI
involved in netrin-activated signaling pathway	IDA IDA: Inferred from direct assay	22685302	MGI
involved in netrin-activated signaling pathway	IGI IGI: Inferred from genetic interaction	22685302	MGI
involved in positive regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	18585357	MGI
acts upstream of or within post-embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	18216855	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	19196994	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22685302	MGI
located in growth cone	IDA IDA: Inferred from direct assay	19196994	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	22685302	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19196994	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cell adhesion molecule DSCAM Down syndrome cell adhesion molecule homolog

Protein Preferred Names

Protein Names

cell adhesion molecule DSCAM

Down syndrome cell adhesion molecule homolog

Dscam Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dscam	Q9ERC8	Dcc	Mus musculus	P70211	Anti Bait CoIP	18585357
Cross	Dscam	Q9ERC8	NTN1	Gallus gallus	Q90922	Anti Tag CoIP	18585357
Cross	Dscam	Q9ERC8	NTN1	Gallus gallus	Q90922	Anti Bait CoIP	18585357
Cross	Dscam	Q9ERC8	NTN1	Gallus gallus	Q90922	IF	18585357
Cross	Dscam	Q9ERC8	Dcc	Rattus norvegicus	Q63155	Anti Tag CoIP	18585357

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04017	DSCAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21560	Dscam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28078	Dscam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dscam	NCBI	NCBI:1826