Dst - dystonin Gene

Also Known as ah; dt; Bpag; BP230; Bpag1; Macf2; nmf203; nmf339; BPAG1-n; athetoid; mKIAA0728; 2310001O04Rik; A830042E19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13518

Summary

Enables microtubule binding activity and protein homodimerization activity. Involved in Cytoskeleton organization and intracellular transport. Acts upstream of or within several processes, including cytoplasmic microtubule organization; regulation of microtubule polymerization or depolymerization; and retrograde axonal transport. Located in several cellular components, including cytoskeleton; endoplasmic reticulum; and sarcomere. Is active in type III intermediate filament. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina nuclear layer. Used to study hereditary sensory and autonomic neuropathy type 6 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Apr 2022]

Dst Products (4)

mRNA Protein Name
NM_001276764.1 NP_001263693.1 dystonin isoform 1
NM_010081.3 NP_034211.2 dystonin isoform 4
NM_133833.4 NP_598594.2 dystonin isoform 3
NM_134448.4 NP_604443.2 dystonin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9971739 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
14576348 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
1634998 MGI
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
19932097 MGI
involved in intracellular transport IDA
IDA: Inferred from direct assay
14576348 MGI
acts upstream of or within retrograde axonal transport IMP
IMP: Inferred from mutant phenotype
14581450 MGI
involved in retrograde axonal transport IMP
IMP: Inferred from mutant phenotype
17287360 MGI
Cellular Component GO Annotation Evidence References Source
located in H zone IDA
IDA: Inferred from direct assay
20209123 MGI
is active in Z disc IDA
IDA: Inferred from direct assay
19932097 MGI
located in Z disc IDA
IDA: Inferred from direct assay
19932097 MGI
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
14576348 MGI
located in axon IDA
IDA: Inferred from direct assay
17287360 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19932097 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
16289082 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18638474 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
14576348 MGI
located in hemidesmosome IDA
IDA: Inferred from direct assay
7736575 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
19932097 MGI
is active in intermediate filament IDA
IDA: Inferred from direct assay
19932097 MGI
located in membrane IDA
IDA: Inferred from direct assay
16289082 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
16289082 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
18638474 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14576348 MGI
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
16289082 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16289082 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
20209123 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
14576348 MGI
is active in type III intermediate filament IDA
IDA: Inferred from direct assay
19932097 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dystonin

  • BPA

  • dystonia musculorum protein

  • hemidesmosomal plaque protein

  • microtubule actin cross-linking factor 2

Dst Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dst Q91ZU6 Prph Rattus norvegicus P21807
Far-WB
9971739
Cross
Dst Q91ZU6 Prph Rattus norvegicus P21807
Y2H
9971739
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04028 DST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174709 Human FGF12 mRNA / Unkown
HY-RS18446 Dst Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24928 Dst Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dst NCBI NCBI:667