Efnb3 - ephrin B3 Gene

Also Known as Epl8; EFL-6; ELF-3; Elk-L3; LERK-8; NLERK-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13643

Summary

Predicted to enable Ephrin Receptor binding activity. Involved in negative regulation of axonogenesis and trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission. Acts upstream of or within T cell costimulation; adult walking behavior; and axon choice point recognition. Located in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study movement disease. Orthologous to human EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Apr 2022]

Efnb3 Products (1)

mRNA Protein Name
NM_007911.5 NP_031937.1 ephrin-B3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18632560 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
15599401 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
11182083 MGI
acts upstream of or within axon choice point recognition IMP
IMP: Inferred from mutant phenotype
11182083 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
11731465 MGI
involved in negative regulation of axonogenesis IDA
IDA: Inferred from direct assay
12383247 MGI
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IDA
IDA: Inferred from direct assay
16571754 MGI
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
16571754 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16571754 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16571754 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
16571754 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
16571754 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16571754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin-B3

Recombinant Efnb3 Proteins

Cat. No. Product Name Accession Purity
HY-P75228 Ephrin B3 Protein, Mouse (HEK293, His) O35393 (L28-A227) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75229 Ephrin B3 Protein, Mouse (HEK293, hFc) O35393 (L28-A227) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04199 EFNB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17547 Efnb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24006 Efnb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Efnb3 NCBI NCBI:1949