Elk1 - ELK1, member of ETS oncogene family Gene

Also Known as Elk-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13712

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]

Elk1 Products (1)

mRNA Protein Name
NM_007922.5 NP_031948.4 ETS domain-containing protein Elk-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12473665 MGI
enables mediator complex binding IPI
IPI: Inferred from physical interaction
7738173 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16549787 MGI
enables transcription regulator activator activity IMP
IMP: Inferred from mutant phenotype
7738173 MGI
enables transcription regulator inhibitor activity IMP
IMP: Inferred from mutant phenotype
7738173 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
31877385 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
31877385 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
31877385 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15896720 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12473665 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ETS domain-containing protein Elk-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152860 Darizmetinib 99.94% Unkown
HY-135699 TD52 95.0% Unkown
HY-113592 ERK-IN-4 Inhibitor 98.30% Unkown
HY-135699A TD52 dihydrochloride 99.55% Unkown
HY-RS04305 ELK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W585976 Benzo[a]pyrene diol epoxide / Unkown
HY-111000 BNC-1 / Unkown
HY-163323 AKR1C3-IN-12 / Unkown
HY-RS07131 KCNH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122241 MT477 Inhibitor / Unkown
HY-RS17329 Elk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21611 Kcnh8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23784 Elk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28129 Kcnh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Elk1 NCBI NCBI:2002