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Ercc1 - excision repair cross-complementing rodent repair deficiency, complementation group 1 Gene

Also Known as Ercc-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13870

Summary

Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Involved in positive regulation of t-circle formation and t-circle formation. Acts upstream of or within several processes, including DNA metabolic process; UV protection; and gamete generation. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Is expressed in brain; cerebral cortex; and telencephalon. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone Cancer (multiple); carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; hematologic Cancer (multiple); and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, Endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc1 Products (3)

mRNA	Protein	Name
NM_001127324.2	NP_001120796.1	DNA excision repair protein ERCC-1 isoform b
NM_001412411.1	NP_001399340.1	DNA excision repair protein ERCC-1 isoform c
NM_007948.3	NP_031974.2	DNA excision repair protein ERCC-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TFIID-class transcription factor complex binding	IDA IDA: Inferred from direct assay	22323595	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22323595	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22323595	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	9197240	MGI
acts upstream of or within DNA recombination	IMP IMP: Inferred from mutant phenotype	11707424	MGI
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	12466203	MGI
acts upstream of or within UV protection	IMP IMP: Inferred from mutant phenotype	8275084	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	10834928	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	15692571	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	15199134	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	17183314	MGI
NOT acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	11707424	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	15199134	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	17912366	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17183314	MGI
acts upstream of or within interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	23637614	MGI
acts upstream of or within isotype switching	IMP IMP: Inferred from mutant phenotype	15280420	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	17912366	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	22323595	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17183314	MGI
acts upstream of or within nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	8275084	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	12466203	MGI
involved in positive regulation of t-circle formation	IMP IMP: Inferred from mutant phenotype	22579284	MGI
acts upstream of or within positive regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22323595	MGI
acts upstream of or within post-embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	15692571	MGI
acts upstream of or within pyrimidine dimer repair by nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	10454634	MGI
acts upstream of or within replicative senescence	IMP IMP: Inferred from mutant phenotype	9197240	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	15979950	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	12466203	MGI
acts upstream of or within syncytium formation	IMP IMP: Inferred from mutant phenotype	10834928	MGI
involved in t-circle formation	IMP IMP: Inferred from mutant phenotype	22579284	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IPI IPI: Inferred from physical interaction	22323595	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA excision repair protein ERCC-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100690	NSC16168	Inhibitor	98.11%	Unkown
HY-147356	ERCC1-XPF-IN-2	Inhibitor	98.54%	Unkown
HY-143498	ERCC1-XPF-IN-1	Inhibitor	99.37%	Unkown
HY-RS04478	ERCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-161623	ERCC1/XPA interaction inhibitor 1	Inhibitor	/	Unkown
HY-RS18274	Ercc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24752	Ercc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ercc1	NCBI	NCBI:2067