Ereg - epiregulin Gene

Also Known as EPR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13874

Summary

Enables epidermal growth factor receptor binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of mitotic nuclear division. Located in extracellular space. Is expressed in several structures, including brain; extraembryonic component; lung; ovary; and skin. Human ortholog(s) of this gene implicated in extrapulmonary tuberculosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human EREG (Epiregulin). [provided by Alliance of Genome Resources, Apr 2022]

Ereg Products (1)

mRNA Protein Name
NM_007950.2 NP_031976.1 proepiregulin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IDA
IDA: Inferred from direct assay
7706296 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
7706296 MGI
enables receptor ligand activity IGI
IGI: Inferred from genetic interaction
28783046 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
7706296 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IGI
IGI: Inferred from genetic interaction
28783046 MGI
Biological Process GO Annotation Evidence References Source
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
7706296 MGI
involved in epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
28783046 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
7706296 MGI
involved in positive regulation of DNA replication IDA
IDA: Inferred from direct assay
7706296 MGI
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
7706296 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
16182244 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
16182244 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
16182244 MGI
involved in positive regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
7706296 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9337852 MGI
is active in extracellular space IGI
IGI: Inferred from genetic interaction
28783046 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proepiregulin

Recombinant Ereg Proteins

Cat. No. Product Name Accession Purity
HY-P75226 Epiregulin Protein, Mouse (HEK293, hFc) Q61521 (V56-L101) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04487 EREG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16966 Ereg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174716 Human EREG mRNA / Unkown
HY-RS23409 Ereg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992137 Turigrobart Inhibitor 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ereg NCBI NCBI:2069