CHODL - chondrolectin Gene

Also Known as MT75; PRED12; C21orf68

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140578

About CHODL

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:17,917,340-18,267,370 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in testis (RPKM 14.8), spleen (RPKM 3.6) and 5 other tissues.

Summary

This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In Other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

CHODL Products (6)

mRNA Protein Name
NM_001204174.2 NP_001191103.1 chondrolectin isoform b
NM_001204175.2 NP_001191104.1 chondrolectin isoform c
NM_001204176.2 NP_001191105.1 chondrolectin isoform c
NM_001204177.2 NP_001191106.1 chondrolectin isoform d
NM_001204178.2 NP_001191107.1 chondrolectin isoform d
NM_024944.3 NP_079220.2 chondrolectin isoform a precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
12079284 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22042635 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12079284 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHODL Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (51 - 179)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

chondrolectin

  • transmembrane protein MT75

CHODL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHODL Q9H9P2 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
CHODL Q9H9P2 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHODL Proteins

Cat. No. Product Name Accession Purity
HY-P77897 CHODL Protein, Human (HEK293, Fc) Q9H9P2-1 (R22-N216) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Enterokinase Deficiency

  • Enteropeptidase Deficiency

  • Congenital Enterokinase Deficiency

  • Congenital Enteropathy Due To Enteropeptidase Deficiency

  • Deficiency Of Enteropeptidase

  • ENTKD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02651 CHODL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18511 Chodl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24993 Chodl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHODL RGD RGD:1309885
Bos taurus CHODL VGNC VGNC:27308
Mus musculus CHODL MGD MGI:2179069
Canis familiaris CHODL VGNC VGNC:39225
Macaca mulatta CHODL VGNC VGNC:70985
Felis catus CHODL VGNC VGNC:60867
Others CHODL NCBI