F2rl2 - coagulation factor II (thrombin) receptor-like 2 Gene

Also Known as PAR3; F730031A08

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14064

About F2rl2

Chromosome 13: 95,833,361-95,839,247 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 262 orthologues, 16 paralogues and is associated with 3 phenotypes. Biased expression in liver E14.5 (RPKM 6.6), spleen adult (RPKM 5.4) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within blood coagulation and signal transduction. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; skin; and spleen. Orthologous to human F2RL2 (coagulation factor II Thrombin receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]

F2rl2 Products (1)

mRNA Protein Name
NM_010170.4 NP_034300.3 proteinase-activated receptor 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proteinase-activated receptor activity IGI
IGI: Inferred from genetic interaction
26742564 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
26742564 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
26742564 MGI
involved in G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
26742564 MGI
involved in ligand-gated ion channel signaling pathway IDA
IDA: Inferred from direct assay
26742564 MGI
involved in ligand-gated ion channel signaling pathway IGI
IGI: Inferred from genetic interaction
26742564 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
26742564 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
26742564 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16892058 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 119)

7tm_GPCRs

7tm_GPCRs: cl28897 (95 - 365)

7tm_GPCRs

7tm_GPCRs: cd14964 (127 - 148)

7tm_GPCRs

7tm_GPCRs: cd14964 (165 - 187)

7tm_GPCRs

7tm_GPCRs: cd14964 (210 - 226)

7tm_GPCRs

7tm_GPCRs: cd14964 (258 - 281)

7tm_GPCRs

7tm_GPCRs: cd14964 (298 - 320)

7tm_GPCRs

7tm_GPCRs: cd14964 (335 - 360)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

proteinase-activated receptor 3

  • PAR-3

  • Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)

  • coagulation factor II receptor-like 2

  • protease-activated receptor 3

  • thrombin receptor-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2rl2 NCBI NCBI:2151