F2RL2 - coagulation factor II thrombin receptor like 2 Gene

Also Known as PAR3; PAR-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2151

About F2RL2

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,615,482-76,623,403 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 16 paralogues. Biased expression in gall bladder (RPKM 4.3), endometrium (RPKM 1.5) and 10 other tissues.

Summary

This gene encodes a member of the Protease-activated Receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the Protease-activated Receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

F2RL2 Products (2)

mRNA Protein Name
NM_004101.4 NP_004092.1 proteinase-activated receptor 3 isoform 1 precursor
NM_001256566.2 NP_001243495.1 proteinase-activated receptor 3 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16458856 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
16458856 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2RL2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (112 - 358)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

proteinase-activated receptor 3

  • Coagulation factor II receptor-like 2 (protease-actovated receptor 3)

  • protease-activated receptor 3

  • thrombin receptor-like 2

F2RL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
F2RL2 O00254 NCK1 Homo sapiens P16333
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thrombosis

  • Thrombosis Of Blood Vessel
Achondroplasia

  • Achondroplastic Dwarfism

  • ACH

  • Osteosclerosis Congenita

  • Achondroplastic Physique

  • Chondrodystrophia

  • Dwarf, Achondroplastic

  • Achondroplastic Short Stature

  • Congenital Osteosclerosis
Thrombophlebitis Migrans
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris F2RL2 VGNC VGNC:53169
Macaca mulatta F2RL2 VGNC VGNC:72465
Rattus norvegicus F2RL2 RGD RGD:620871
Mus musculus F2RL2 MGD MGI:1298208
Bos taurus F2RL2 VGNC VGNC:28685
Felis catus F2RL2 VGNC VGNC:102198
Others F2RL2 NCBI