Gpr6 - G protein-coupled receptor 6 Gene

Also Known as Gm233

Species: Mus musculus

Gene Type: protein coding
Gene ID: 140741

About Gpr6

Chromosome 10: 40,945,973-40,948,281 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 186 orthologues, 18 paralogues and is associated with 3 phenotypes. Biased expression in cortex adult (RPKM 1.6), CNS E18 (RPKM 1.2) and 7 other tissues.

Summary

Enables sphingosine-1-phosphate receptor activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; eye; immune system; male reproductive gland or organ; and nervous system. Orthologous to human GPR6 (G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Gpr6 Products (1)

mRNA Protein Name
NM_199058.2 NP_951013.1 G-protein coupled receptor 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sphingosine-1-phosphate receptor activity IDA
IDA: Inferred from direct assay
14592418 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
14592418 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr6 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (73 - 340)

7tm_GPCRs

7tm_GPCRs: cd14964 (75 - 99)

7tm_GPCRs

7tm_GPCRs: cd14964 (108 - 129)

7tm_GPCRs

7tm_GPCRs: cd14964 (142 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (187 - 203)

7tm_GPCRs

7tm_GPCRs: cd14964 (223 - 246)

7tm_GPCRs

7tm_GPCRs: cd14964 (278 - 300)

7tm_GPCRs

7tm_GPCRs: cd14964 (308 - 333)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 6

  • sphingosine 1-phosphate receptor GPR6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-134661A Solangepras 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134661 (S)-CVN424 99.16% Unkown
HY-182011 GPR6 inverse agonist 2 Agonist / Unkown
HY-181349 GPR6 inverse agonist 1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr6 NCBI NCBI:2830