Ddit4 - DNA-damage-inducible transcript 4 Gene

Also Known as Rtp801

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140942

Summary

Predicted to enable 14-3-3 protein binding activity. Involved in several processes, including negative regulation of protein phosphorylation; nervous system development; and neurotrophin Trk Receptor signaling pathway. Predicted to be located in cytosol and mitochondrion. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Apr 2022]

Ddit4 Products (1)

mRNA Protein Name
NM_080906.2 NP_543182.1 DNA damage-inducible transcript 4 protein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
21368030 RGD
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
19118169 RGD
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
21368030 RGD
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
21368030 RGD
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
21368030 RGD
involved in neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21368030 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
11884613 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA damage-inducible transcript 4 protein

  • HIF-1 responsive RTP801

  • HIF-1 responsive protein RTP801

  • REDD-1

  • protein regulated in development and DNA damage response 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03615 DDIT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16246 Ddit4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23835 Ddit4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddit4 NCBI NCBI:54541