Fat1 - FAT atypical cadherin 1 Gene

Also Known as Fath; mFat1; 2310038E12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14107

Summary

Involved in epithelial cell morphogenesis; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis; and lens development in camera-type eye. Acts upstream of or within actin filament organization; cell-cell adhesion; and establishment or maintenance of cell polarity. Located in several cellular components, including apical plasma membrane; filopodium; and lamellipodium. Is active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study facioscapulohumeral muscular dystrophy and nephrotic syndrome. Orthologous to human FAT1 (FAT atypical Cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fat1 Products (1)

mRNA Protein Name
NM_001081286.2 NP_001074755.2 protocadherin Fat 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15148305 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
15148305 MGI
involved in camera-type eye development IMP
IMP: Inferred from mutant phenotype
26114487 MGI
involved in camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
26114487 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15148305 MGI
involved in epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
26114487 MGI
involved in establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
26114487 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
15148305 MGI
involved in establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
26114487 MGI
involved in lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
26114487 MGI
Cellular Component GO Annotation Evidence References Source
is active in apical plasma membrane IDA
IDA: Inferred from direct assay
26114487 MGI
located in cell junction IDA
IDA: Inferred from direct assay
15148305 MGI
located in filopodium IDA
IDA: Inferred from direct assay
15148305 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15148305 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
26114487 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protocadherin Fat 1

  • FAT tumor suppressor homolog 1

  • fat 1 cadherin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115319 CP-24879 hydrochloride 99.59% Unkown
HY-113422 Tetrahydrocorticosterone 99.90% Unkown
HY-124141 Myristelaidic acid 99.80% Unkown
HY-W160407 9-Decenoic acid 98.56% Unkown
HY-135297 Mono-and diglycerides 97.50% Unkown
HY-113422S2 Tetrahydrocorticosterone-d3-1 / Unkown
HY-B1567 Bromocyclen / Unkown
HY-RS04760 FAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Y0781S6 Pyruvic acid-13C-4 / Unkown
HY-116846 Methyldymron / Unkown
HY-166088 Myristelaidic acid sodium / Unkown
HY-168386 1,2-Dipalmitoyl-3-Myristoyl-rac-glycerol 99.29% Unkown
HY-RS18131 Fat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24605 Fat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fat1 NCBI NCBI:2195