Ms4a2 - membrane-spanning 4-domains, subfamily A, member 2 Gene

Also Known as FcRB; Fce1b; Ms4a1; fcERI; Fcer1b; Fcrbeta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14126

Summary

This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Ms4a2 Products (4)

mRNA Protein Name
NM_001276328.1 NP_001263257.1 high affinity immunoglobulin epsilon receptor subunit beta isoform b
NM_001276329.1 NP_001263258.1 high affinity immunoglobulin epsilon receptor subunit beta isoform c
NM_001276330.1 NP_001263259.1 high affinity immunoglobulin epsilon receptor subunit beta isoform d
NM_013516.2 NP_038544.1 high affinity immunoglobulin epsilon receptor subunit beta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to IgE binding IDA
IDA: Inferred from direct assay
14764707 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
9000133 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12192036 MGI
Cellular Component GO Annotation Evidence References Source
part of Fc-epsilon receptor I complex IDA
IDA: Inferred from direct assay
14764707 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
2527850 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
2527850 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit beta

  • Fc receptor, IgE, high affinity I, beta polypeptide

  • fc epsilon receptor I beta-chain

  • membrane-spanning 4-domains, subfamily A, member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08700 MS4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a2 NCBI NCBI:2206