Fer - fer (fms/fps related) protein kinase Gene

Also Known as Fer; Fert; Fert2; C330004K01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14158

Summary

Enables protein kinase activity and protein Phosphatase 1 binding activity. Involved in several processes, including cell surface receptor signaling pathway; cell-cell adhesion mediated by cadherin; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including cell adhesion; chemotaxis; and protein autophosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Is expressed in central nervous system and retina. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fer Products (6)

mRNA Protein Name
NM_001037997.4 NP_001033086.2 tyrosine-protein kinase Fer isoform a
NM_001286415.1 NP_001273344.1 tyrosine-protein kinase Fer isoform c
NM_001403359.1 NP_001390288.1 tyrosine-protein kinase Fer isoform d
NM_001403360.1 NP_001390289.1 tyrosine-protein kinase Fer isoform d
NM_001403361.1 NP_001390290.1 tyrosine-protein kinase Fer isoform e
NM_008000.2 NP_032026.2 tyrosine-protein kinase Fer isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12200133 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12192036 MGI
enables protein phosphatase 1 binding IPI
IPI: Inferred from physical interaction
16732323 MGI
Biological Process GO Annotation Evidence References Source
involved in Fc-epsilon receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12192036 MGI
involved in Kit signaling pathway IMP
IMP: Inferred from mutant phenotype
12192036 MGI
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16176974 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
12192036 MGI
involved in cell-cell adhesion mediated by cadherin IMP
IMP: Inferred from mutant phenotype
16176974 MGI
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
17606629 MGI
acts upstream of or within chemotaxis IMP
IMP: Inferred from mutant phenotype
12192036 MGI
involved in diapedesis IMP
IMP: Inferred from mutant phenotype
16009680 MGI
involved in extracellular matrix-cell signaling IMP
IMP: Inferred from mutant phenotype
17606629 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
11006284 MGI
involved in negative regulation of mast cell activation involved in immune response IMP
IMP: Inferred from mutant phenotype
16731527 MGI
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
7623846 MGI
acts upstream of positive effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
11006284 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
12192036 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12192036 MGI
involved in regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
17606629 MGI
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16732323 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
16009680 MGI
involved in response to platelet-derived growth factor IDA
IDA: Inferred from direct assay
7623846 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12192036 MGI
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
16176974 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Fer

  • fer (fms/fps related) protein kinase, testis specific 2

  • p94-Fer

  • proto-oncogene c-Fer

  • proto-oncogene tyrosine-protein kinase Fer

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-122844 Ifebemtinib Inhibitor 99.86% Phase 2
HY-10338A Foretinib phosphate Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100579 Ferrostatin-1 Inhibitor 99.96% Unkown
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-112097 E260 Inhibitor 99.92% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-128576 DS21360717 99.80% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-P10229 RALF1 peptide Activator 98.69% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-156066 Ferrostatin-1 diyne Inhibitor 99.9% Unkown
HY-125142 AP-24567 / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-161731 DS08701581 Inhibitor / Unkown
HY-RS04862 FER Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04863 FER1L6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16564 Fer Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22996 Fer Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fer NCBI NCBI:2241