Fkbp5 - FK506 binding protein 5 Gene

Also Known as Dit1; FKBP-5; FKBP51; D17Ertd592e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14229

Summary

Predicted to enable heat shock protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp5 Products (1)

mRNA Protein Name
NM_010220.4 NP_034350.1 peptidyl-prolyl cis-trans isomerase FKBP5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11751894 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP5

  • 51 kDa FK506-binding protein

  • 51 kDa FKBP

  • PPIase FKBP5

  • rotamase

Fkbp5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fkbp5 Q64378 Nr3c1 Mus musculus P06537
CoIP
11751894
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135794 11-Ketodihydrotestosterone Agonist 99.87% Unkown
HY-136242 UT-34 Degrader 98.09% Unkown
HY-168201 MJP6412 95.90% Unkown
HY-RS04965 FKBP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16916 Fkbp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23358 Fkbp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp5 NCBI NCBI:2289