Fth1 - ferritin heavy polypeptide 1 Gene

Also Known as FHC; Fth; HFt; MFH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14319

Summary

Enables iron ion binding activity. Acts upstream of or within iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to human FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Fth1 Products (1)

mRNA Protein Name
NM_010239.2 NP_034369.1 ferritin heavy chain

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
11591653 MGI
enables iron ion binding IDA
IDA: Inferred from direct assay
21886823 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within iron ion transport IDA
IDA: Inferred from direct assay
21886823 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
29074498 MGI
is active in membrane IDA
IDA: Inferred from direct assay
29074498 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ferritin heavy chain

  • H-ferritin

  • ferritin H subunit

  • ferritin heavy chain 1

Fth1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fth1 P09528 Fth1 Mus musculus P09528
3D-EM
32647824
Intra
Fth1 P09528 Fth1 Mus musculus P09528
Y2H Array
11591653
Intra
Fth1 P09528 Ftl1 Mus musculus Q9CPX4
Y2H Array
11591653
Intra
Fth1 P09528 Fth1 Mus musculus P09528
3D-EM
33087931
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-167874 ASP-8731 Inhibitor 98.42% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148409 MMRi62 99.59% Unkown
HY-N11849 Moracin N 99.74% Unkown
HY-RS05133 FTH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174345 Ferroptosis inducer-8 / Unkown
HY-174867 AY-4 Agonist / Unkown
HY-174871 AY-2 / Unkown
HY-176271 MAO-B-IN-45 / Unkown
HY-179384 PROTAC FSP1 degrader 1 / Unkown
HY-184667 β-Lactamase/Ferroptosis-IN-1 / Unkown
HY-RS16862 Fth1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23303 Fth1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fth1 NCBI NCBI:2495