CSNK2A2 - casein kinase 2 alpha 2 Gene

Also Known as CK2A2; CSNK2A1; CK2alpha'

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1459

About CSNK2A2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,157,907-58,198,106 (from NCBI)

This gene has 8 transcripts (splice variants), 290 orthologues and 2 paralogues. Broad expression in testis (RPKM 55.0), skin (RPKM 19.3) and 24 other tissues.

Summary

This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, Casein Kinase 2 (CK2). Casein Kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, Apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]

CSNK2A2 Products (1)

mRNA	Protein	Name
NM_001896.4	NP_001887.1	casein kinase II subunit alpha'

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10094392	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20545769	GOA
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	28031292	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair	IDA IDA: Inferred from direct assay	22325354	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	28031292	GOA
involved in regulation of chromosome separation	IMP IMP: Inferred from mutant phenotype	11704824	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK2A2 Protein Structure

Pkinase

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
casein kinase II subunit alpha'	CK II alpha'

CSNK2A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	TAP	23455922
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	33961781
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	28514442
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	Y2H	19011756
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	Pull Down	32707033
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	TAP	27705803
Intra	CSNK2A2	P19784	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	35271311
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	33961781
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	TAP	23455922
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Validated Y2H	32296183
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Y2H Array	32296183
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Pull Down	32707033
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	35271311
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Y2H Prey Pooling	32296183
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Y2H	21988832
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	26496610
Intra	CSNK2A2	P19784	CSNK2B	Homo sapiens	P67870	TAP	27705803
Intra	CSNK2A2	P19784	KIF5C	Homo sapiens	O60282	IF	19011756
Intra	CSNK2A2	P19784	KIF5C	Homo sapiens	O60282	Y2H	19011756
Intra	CSNK2A2	P19784	KIF5C	Homo sapiens	O60282	Protein Kinase Assay	19011756
Intra	CSNK2A2	P19784	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	CSNK2A2	P19784	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	25416956
Intra	CSNK2A2	P19784	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	CSNK2A2	P19784	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	CSNK2A2	P19784	ZNF670	Homo sapiens	Q9BS34	Validated Y2H	32296183
Intra	CSNK2A2	P19784	ZNF670	Homo sapiens	Q9BS34	Y2H	21988832
Intra	CSNK2A2	P19784	ZNF670	Homo sapiens	Q9BS34	Y2H Array	32296183
Intra	CSNK2A2	P19784	ZNF670	Homo sapiens	Q9BS34	Y2H Prey Pooling	32296183
Intra	CSNK2A2	P19784	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CSNK2A2	P19784	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CSNK2A2	P19784	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSNK2A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76296	CK2 alpha/CSNK2A2 Protein, Human (sf9)	P19784 (N-G&P, M1-R350)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76297	CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST)	P19784 (M1-R350)	≥ 90%, as determined by reducing SDS-PAGE.

CSNK2A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84160	CSNK2A2 Antibody (YA3857)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84160A	CSNK2A2 Antibody (YA3857)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit

Related Diseases

Diseases	Alias
Theileriasis	Theileriosis Infection By Theileria
Spermatogenic Failure 6	Globozoospermia SPGF6 Round-Headed Spermatozoa Acrosome Malformation Of Spermatozoa Spermatogenic Failure 9 Spermatozoa, Round-Headed Globozoospermia, Complete Globozoospermia, Total Mae Infertility Due To Round-Headed Spermatozoa Male Infertility Due To Globozoospermia Male Infertility Due To Round-Headed Spermatozoa Round-Headed Sperm Syndrome Spgf9 Teratozoospermia
Okur-Chung Neurodevelopmental Syndrome	OCNDS Csnk2a1-Related Neurodevelopmental Syndrome
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Neonatal Leukemia
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163182	CSNK2A-IN-2	Inhibitor	/	Unkown
HY-RS03252	CSNK2A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163783	CSNK2-IN-1	Inhibitor	/	Unkown
HY-168595	CSNK2-IN-2	Inhibitor	/	Unkown
HY-RS18722	Csnk2a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25209	Csnk2a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSNK2A2	RGD	RGD:1306882
Mus musculus	CSNK2A2	MGD	MGI:88547
Canis familiaris	CSNK2A2	VGNC	VGNC:39670
Macaca mulatta	CSNK2A2	VGNC	VGNC:71524
Bos taurus	CSNK2A2	VGNC	VGNC:27769
Felis catus	CSNK2A2	VGNC	VGNC:61226
Others	CSNK2A2	NCBI