B4galt1 - UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 Gene

Also Known as GalT; Ggtb; Ggtb2; b4Gal-T1; B-1,4-GalT; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14595

Summary

This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These Enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]

B4galt1 Products (4)

mRNA Protein Name
NM_001378519.2 NP_001365448.1 beta-1,4-galactosyltransferase 1 isoform 2
NM_022305.6 NP_071641.1 beta-1,4-galactosyltransferase 1 isoform 1
NM_001378519.2 NP_001365448.1 beta-1,4-galactosyltransferase 1 isoform 2
NM_022305.6 NP_071641.1 beta-1,4-galactosyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IDA
IDA: Inferred from direct assay
9813328 MGI
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IMP
IMP: Inferred from mutant phenotype
9013935 MGI
enables galactosyltransferase activity IDA
IDA: Inferred from direct assay
7641815 MGI
enables lactose synthase activity IMP
IMP: Inferred from mutant phenotype
9155011 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8089187 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acute inflammatory response IMP
IMP: Inferred from mutant phenotype
12714507 MGI
acts upstream of or within angiogenesis involved in wound healing IMP
IMP: Inferred from mutant phenotype
15039218 MGI
acts upstream of or within binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
9374408 MGI
acts upstream of or within binding of sperm to zona pellucida IPI
IPI: Inferred from physical interaction
8089187 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
12714507 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of or within development of secondary sexual characteristics IMP
IMP: Inferred from mutant phenotype
11900463 MGI
acts upstream of or within epithelial cell development IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
11900463 MGI
acts upstream of or within galactose metabolic process IDA
IDA: Inferred from direct assay
9813328 MGI
acts upstream of or within glycoprotein biosynthetic process IMP
IMP: Inferred from mutant phenotype
10381349 MGI
acts upstream of or within lactose biosynthetic process IMP
IMP: Inferred from mutant phenotype
9155011 MGI
involved in lactose biosynthetic process IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of or within macrophage migration IMP
IMP: Inferred from mutant phenotype
15039218 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of or within oligosaccharide biosynthetic process IDA
IDA: Inferred from direct assay
9813328 MGI
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
9374408 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15282149 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in wound healing IMP
IMP: Inferred from mutant phenotype
15039218 MGI
acts upstream of or within protein glycosylation IMP
IMP: Inferred from mutant phenotype
9155011 MGI
acts upstream of or within regulation of acrosome reaction IMP
IMP: Inferred from mutant phenotype
9374408 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
15039218 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
2503706 MGI
located in cell surface IDA
IDA: Inferred from direct assay
9374408 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
2503706 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
11485999 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-1,4-galactosyltransferase 1

  • N-acetyllactosamine synthase

  • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

  • b1,4-Galactosyltransferase I

  • beta-1,4-GalTase 1

  • beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

  • beta-N-acetylglucosaminylglycopep

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70289 Bovin beta-1,4-galactosyltransferase 1 (Y289L) / Unkown
HY-E70285 beta-1,4-Galactosyltransferase 1 (Y285L) / Unkown
HY-E70046 β-1,4-Galactosyltransferase, neisseria meningitides / Unkown
HY-E70046A Bovine beta-1,4-Galactosyltransferase / Unkown
HY-RS01319 B4GALT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18013 B4galt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24486 B4galt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens B4galt1 NCBI NCBI:2683