Got2 - glutamatic-oxaloacetic transaminase 2, mitochondrial Gene

Also Known as Got-2; Kyat4; mAspAT; FABP-pm

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14719

Summary

Enables L-aspartate:2-oxoglutarate aminotransferase activity. Acts upstream of or within dicarboxylic acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Got2 Products (1)

mRNA Protein Name
NM_010325.3 NP_034455.1 aspartate aminotransferase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
869894 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aspartate biosynthetic process IDA
IDA: Inferred from direct assay
4193185 MGI
acts upstream of or within glutamate catabolic process IDA
IDA: Inferred from direct assay
4193185 MGI
acts upstream of or within glutamate catabolic process to aspartate IDA
IDA: Inferred from direct assay
4193185 MGI
involved in malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
34450065 MGI
acts upstream of or within oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
4193185 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
4193185 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
4193185 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aspartate aminotransferase, mitochondrial

  • FABP-1

  • FABPpm

  • fatty acid-binding protein

  • glutamate oxaloacetate transaminase 2, mitochondrial

  • kynurenine aminotransferase 4

  • kynurenine aminotransferase IV

  • kynurenine--oxoglutarate transaminase 4

  • kynurenine--oxoglutarate transaminase IV

  • mitochondri

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05606 GOT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17809 Got2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24277 Got2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Got2 NCBI NCBI:2806