GOT2 - glutamic-oxaloacetic transaminase 2 Gene

Also Known as KAT4; DEE82; KATIV; KYAT4; mitAAT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2806

About GOT2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,707,131-58,734,316 (from NCBI)

This gene has 7 transcripts (splice variants), 252 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 129.5), liver (RPKM 91.0) and 24 other tissues.

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two Enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GOT2 Products (2)

mRNA Protein Name
NM_001286220.2 NP_001273149.1 aspartate aminotransferase, mitochondrial isoform 2 precursor
NM_002080.4 NP_002071.2 aspartate aminotransferase, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
2182221 GOA
Biological Process GO Annotation Evidence References Source
involved in aspartate catabolic process IDA
IDA: Inferred from direct assay
2567216 GOA
involved in fatty acid transport IEP
IEP: Inferred from expression pattern
9537447 GOA
involved in response to ethanol IDA
IDA: Inferred from direct assay
9537447 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
9537447 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9537447 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOT2 Protein Structure

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (58 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 430 a.a.
Protein Preferred Names Protein Names

aspartate aminotransferase, mitochondrial

  • FABP-1

GOT2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81273B liver FABP Antibody (YA967) WB, IHC-F, IHC-P, ICC/IF Mouse
HY-P81273BA liver FABP Antibody (YA967)(PBS only) WB, IHC-F, IHC-P, ICC/IF Mouse
HY-P83117 GOT2 Antibody (YA2862) WB, IHC-P, IP Human, Mouse, Rat
HY-P83890 GOT2 Antibody (YA3587) WB, ICC/IF, ELISA Human, Mouse, Rat, Monkey
HY-P83890A GOT2 Antibody (YA3587)(PBS only) WB, ICC/IF, ELISA Human, Mouse, Rat, Monkey
HY-P85630 GOT2 Antibody (YA5322) WB Human, Mouse

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 82

  • DEE82

  • Epileptic Encephalopathy, Early Infantile, 82

  • Eiee82

  • Got2 Deficiency

  • Developmental And Epileptic Encephalopathy, 82

  • Glutamate Oxaloacetate Transaminase, Mitochondrial, Deficiency Of

  • Early Infantile Epileptic Encephalopathy 82

  • Deficiency Of Mitochondrial Glutamate Oxaloacetate Transaminase
Developmental And Epileptic Encephalopathy

  • Encephalopathy, Developmental And Epileptic
Acute Vascular Insufficiency Of Intestine

  • Acute Gastrointestinal Tract Vascular Insuffic.

  • Acute Git Vascular Insuffic.

  • Acute Intestinal Ischemia

  • Acute Intestinal Vascular Insufficiency
Early Infantile Epileptic Encephalopathy

  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile
Chronic Intestinal Vascular Insufficiency

  • Chronic Mesenteric Ischemia

  • Cmi - Chronic Mesenteric Ischaemia
Liver Benign Neoplasm

  • Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Median Arcuate Ligament Syndrome

  • Celiac Artery Compression Syndrome

  • Dunbar Syndrome

  • Mals

  • Harjola-Marable Syndrome

  • Marable'S Syndrome

  • Celiac Axis Syndrome
Neuroschistosomiasis
Fascioliasis

  • Fasciola Hepatica Infection

  • Infection By Fasciola

  • Sheep Liver Fluke Infection

  • Liver Flukes

  • Fasciola Infestation

  • Sheep Liver Fluke Disease

  • Liver Fluke Infestation

  • Liver Flukes Nos

  • Liver Fluke Infection

  • Liver Fluke Disease
Perinatal Necrotizing Enterocolitis

  • Necrotizing Enterocolitis

  • Enterocolitis Necrotizing

  • Enterocolitis, Necrotizing

  • Necrotizing Enterocolitis In Fetus Or Newborn

  • Perinatal Necrotising Enterocolitis

  • Pseudomembranous Enterocolitis In Newborn

  • Nec
Shrimp Allergy
Crustacean Allergy
Hepatocellular Adenoma

  • Adenoma Hepatocellular
Intestinal Schistosomiasis

  • Schistosomiasis Japonica

  • Schistosomiasis Mansoni

  • Katayama Fever

  • Schistosoma Japonicum Infection

  • Schistosoma Mansoni Infectious Disease

  • Schistosomiasis
Clonorchiasis

  • Oriental Liver Fluke Disease

  • Clonorchis Liver Infection

  • Clonorchiosis

  • Chinese Liver Fluke Disease

  • Hepatic Distomiasis Due To Clonorchis Sinensis

  • Infection Due To Clonorchis Sinensis

  • Hepatic Distomiasis

  • Hepatic Distomatosis

  • Chinese Liver Fluke Disorder

  • Oriental Liver Fluke Disorder

  • Clonorchis Infestation

  • Chinese Liver Fluke Infestation

  • Liver Fluke Disease Due To Clonorchis Sinensis

  • Oriental Liver Fluke Infestation
Hydrops Of Gallbladder

  • Gallbladder Hydrops
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05606 GOT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17809 Got2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24277 Got2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GOT2 VGNC VGNC:73112
Mus musculus GOT2 MGD MGI:95792
Felis catus GOT2 VGNC VGNC:97447
Rattus norvegicus GOT2 RGD RGD:2722
Bos taurus GOT2 VGNC VGNC:29503
Others GOT2 NCBI