GOT2 - glutamic-oxaloacetic transaminase 2 Gene

Homo sapiens

Also known as KAT4; DEE82; KATIV; KYAT4; mitAAT

Gene ID: 2806 | Gene type: protein coding

About GOT2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,707,131-58,734,316 (from NCBI)

This gene has 7 transcripts (splice variants), 252 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 129.5), liver (RPKM 91.0) and 24 other tissues.

Summary

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent Enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GOT2 Products(2)

mRNA	Protein	Name
NM_001286220.2	NP_001273149.1	aspartate aminotransferase, mitochondrial isoform 2 precursor
NM_002080.4	NP_002071.2	aspartate aminotransferase, mitochondrial isoform 1 precursor

GOT2 Protein Structure

Aminotran_1_2

0
100
200
300
400
430 a.a.

Protein Preferred Names

Protein Names

aspartate aminotransferase, mitochondrial

FABP-1

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 82

DEE82	Epileptic Encephalopathy, Early Infantile, 82
Eiee82	Got2 Deficiency
Developmental And Epileptic Encephalopathy, 82	Glutamate Oxaloacetate Transaminase, Mitochondrial, Deficiency Of
Early Infantile Epileptic Encephalopathy 82	Deficiency Of Mitochondrial Glutamate Oxaloacetate Transaminase

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.	Acute Git Vascular Insuffic.
Acute Intestinal Ischemia	Acute Intestinal Vascular Insufficiency

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia

Liver Benign Neoplasm

Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm

Median Arcuate Ligament Syndrome

Celiac Artery Compression Syndrome	Dunbar Syndrome
Mals	Harjola-Marable Syndrome
Marable'S Syndrome	Celiac Axis Syndrome

Neuroschistosomiasis

Fascioliasis

Fasciola Hepatica Infection	Infection By Fasciola
Sheep Liver Fluke Infection	Liver Flukes
Fasciola Infestation	Sheep Liver Fluke Disease
Liver Fluke Infestation	Liver Flukes Nos
Liver Fluke Infection	Liver Fluke Disease

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Shrimp Allergy

Crustacean Allergy

Hepatocellular Adenoma

Adenoma Hepatocellular

Intestinal Schistosomiasis

Schistosomiasis Japonica	Schistosomiasis Mansoni
Katayama Fever	Schistosoma Japonicum Infection
Schistosoma Mansoni Infectious Disease	Schistosomiasis

Clonorchiasis

Oriental Liver Fluke Disease	Clonorchis Liver Infection
Clonorchiosis	Chinese Liver Fluke Disease
Hepatic Distomiasis Due To Clonorchis Sinensis	Infection Due To Clonorchis Sinensis
Hepatic Distomiasis	Hepatic Distomatosis
Chinese Liver Fluke Disorder	Oriental Liver Fluke Disorder
Clonorchis Infestation	Chinese Liver Fluke Infestation
Liver Fluke Disease Due To Clonorchis Sinensis	Oriental Liver Fluke Infestation

Hydrops Of Gallbladder

Gallbladder Hydrops

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3	MODY3
Mody, Type Iii	Mody Type 3
Mody, Type 3	Maturity-Onset Diabetes Of The Young 3
Mody-3	Diabetes Of The Young, Maturity-Onset, Type 3

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05606	GOT2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GOT2	VGNC	VGNC:73112
Mus musculus	GOT2	MGD	MGI:95792
Felis catus	GOT2	VGNC	VGNC:97447
Rattus norvegicus	GOT2	RGD	RGD:2722
Bos taurus	GOT2	VGNC	VGNC:29503