TMC4 - transmembrane channel like 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147798

About TMC4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,160,108-54,173,160 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 170 orthologues and 7 paralogues. Broad expression in duodenum (RPKM 27.9), colon (RPKM 25.4) and 14 other tissues.

Summary

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

TMC4 Products (2)

mRNA Protein Name
NM_001145303.3 NP_001138775.2 transmembrane channel-like protein 4 isoform 1
NM_144686.4 NP_653287.2 transmembrane channel-like protein 4 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
34468713 GOA
enables voltage-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
34429071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMC4 Protein Structure

TMC

TMC: TMC domain (475 - 585)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

transmembrane channel-like protein 4

  • testicular tissue protein Li 204

Related Diseases

Diseases Alias
Epidermodysplasia Verruciformis 1

  • Epidermodysplasia Verruciformis

  • Epidermodysplasia Verruciformis, Susceptibility To, 1

  • Lutz-Lewandowsky Epidermodysplasia Verruciformis

  • EV1

  • Lewandowsky-Lutz Syndrome

  • Ev
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14624 TMC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TMC4 VGNC VGNC:35920
Mus musculus TMC4 MGD MGI:2669035
Rattus norvegicus TMC4 RGD RGD:1304811
Felis catus TMC4 VGNC VGNC:66235
Macaca mulatta TMC4 VGNC VGNC:79365
Canis familiaris TMC4 VGNC VGNC:47423
Others TMC4 NCBI